About Robert Sobol

Dr. Robert Sobol joined the faculty of Mitchell Cancer Institute (MCI) in 2014 as the Chief of the Molecular & Metabolic Oncology Program. He also serves as the Point Clear Charities Professor of Oncologic Sciences and an Abraham A. Mitchell Distinguished Investigator. The Molecular & Metabolic Oncology Program focuses on the cellular mechanisms of DNA repair and metabolism and how these processes impact cancer development and the response to cancer treatments. Serving as program director, Sobol works with eight labs, including his new lab, two current MCI labs and five others to be added in the coming years.

Focus

Research in the Sobol lab focuses on the mechanism of base excision repair, PARP and NAD+ metabolism in human cells and the convergent role of these enzymes and pathways in response to environmental Genotoxins and chemotherapy. A major goal in the lab is to use biochemical, genetic and imaging modalities to study the protein complexes of the base excision repair pathway that respond to DNA damage induced by Genotoxins and chemotherapy and how this pathway affects the regulation of cellular metabolism via ADP-ribosylation signaling and alterations in NAD+ metabolism. Dr. Sobol's research has been funded by grants from the National Institutes of Health (NIH), American Cancer Society, the Susan G. Komen Breast Cancer Foundation and the Brain Tumor Society, among others.

Learn more about the DNA Damage and Repair Lab
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Research Interests

  • DNA repair and metabolism's impact on cancer development
  • Base excision repair, PARP and NAD+ metabolism in human cells and the convergent role of these enzymes and pathways in response to environmental Geno toxins and chemotherapy
  • Using biochemical, genetic and imaging modalities to study the protein complexes of the base excision repair pathway that respond to DNA damage induced by Geno toxins and chemotherapy and how this pathway affects the regulation of cellular metabolism via ADP-ribosylation signaling and alterations in NAD+ metabolism

Education

  • Graduate: Chemistry, Temple University | Philadelphia, PA
  • Postgraduate: Biochemistry, Temple University | Philadelphia, PA

Research Location

USA Health has a comprehensive biomedical research program that spans a wide range of clinical, basic and translational research.​ At the Mitchell Cancer Institute, our physicians and scientific investigators are searching for breakthrough discoveries to improve the lives of cancer patients.

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