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21-147 - ARST1921 - A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery

Status: open

ARST1921 - A Safety, Pharmacokinetic and Efficacy Study of a γ-Secretase Inhibitor, Nirogacestat (PF-03084014; IND# 146375), in Children and Adolescents with Progressive, Surgically Unresectable Desmoid Tumors

Desmoid Tumors that cannot be removed by surgery

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To estimate the 2-year progression-free survival (PFS) rate in patients with progressive, surgically unresectable desmoid tumor treated with nirogacestat.


This trial is sponsored by Children's Oncology Group.

Providers Associated With This Trial

Principle Investigator

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