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Yaguang Xi, M.D., Ph.D.

Yaguang Xi, M.D., Ph.D., MBA
Assistant Professor of Oncologic Sciences

USA Mitchell Cancer Institute
1660 Springhill Avenue
Mobile, Alabama 36604
(251) 445-9857

Professional Profile

Research Interests:
- Discovery and validation of novel biomarkers associated with tumor progression, metastasis, therapeutic response, and chemoprevention
- Identification and characterization of important roles of non-coding RNA (microRNAs) in human cancer
- Developing novel normalization methods for microarray analysis

- M.D., Inner Mongolia Medical College, China
- Ph.D., Peking University, China
- MBA, University of South Alabama

Professional Appointments: - Assistant Professor of Oncologic Sciences, USA Mitchell Cancer Institute (2012-present)

Honors and Academic Achievements:
- V-American Society of Clinical Oncology, Merit Award (2008)
- American Association for Cancer Research Aflac Scholar-In-Training Award (2007 & 2008)
- World Health Organization- International Agency for Research on Cancer, Special Training Award, France (2004)
- Outstanding Academic Researcher Award, Peking University, China (2003)
- Innovation Award, Peking University, China (2002)

Professional Memberships:
- American Association for Cancer Research 
- American Society of Clinical Oncology  
- International Honor Society Beta Gamma Sigma

Other Professional Honors / Services:
- Editorial Board Member: Thoracic Cancer, ScientificWorldJournal, Micro RNA, American Medical Journal, and Journal of Integrative Oncology
- Article Reviewer: Annals of Oncology, BBA - General Subjects, BMC Boinformatics, BMC Cancer, BMC Clinical Pathology, BMC genomics, British Journal of Pharmacology, Cancer Genetics, Chemotherapy, Clinical and Experimental Hypertension, Clinical Oncology and Cancer Research, Genomics, Proteomics & Bioinformatics, International Journal of Biomedical Science, International Journal of Cancer, International Journal of Immunogenetics, Journal of Chemotherapy, Journal of Nucleic Acids, Journal of Translational Medicine, Molecular Cancer, Molecular Oncology, Medicinal Research Reviews, Ochsner Journal, and Scientific World Journal
- Grant Reviewer: Peer Reviewed Cancer Research Program, DOD (2012); Research Grant Council (RGC), Hong Kong (2012); and Genesis Oncology Trust, New Zealand (2011) 

Selected Publications:
1. Wang, B., Zhang, S.G., Wang, X.F., Tan, M., Xi, Y. (2012) Testing for differentially-expressed microRNAs with errors-in-variables nonparametric regression. PLoS ONE. 7(5):e37537  

2. Whitt, J.D., Li, N., Tinsley, H.N., Chen, X., Zhang, W., Li, Y., Gary, B.D., Keeton, A.B., Xi, Y., Abadi, A.H., Grizzle, W.E., Piazza, G.A. (2012) A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and beta-catenin transcriptional activity. Cancer Prev Res. 5(6):822-33.  

3. Li, X., Gao, L., Cui, Q., Gary, B., Dyness, D.L., Taylor, W., Shevde-Samant, L.R., Samant, R.S., Dean-Colomb, W., Piazza, G.A., Xi, Y. (2012) Sulindac inhibits tumor cell invasion by suppressing NF-kappaB mediated transcription of microRNAs. Oncogene. In press. doi: 10.1038/onc.2011.655.  

4. Gao, L., Gao, Y., Li, X., Howell, P., Kumar, R., Su, X., Vlassov, A.V., Piazza, GA., Riker, A.I., Sun, D., Xi, Y. (2012) Aquaporins mediate the chemoresistance of human melanoma cells to arsenite. Mol Oncol. 6(1):81-87  

5. Li, X., Zhang, J., Gao, L., McClellan, S., Finan, M., Butler, T.W., Owen, L.B., Piazza, G.A., Xi, Y. (2012) MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit. Cell Death Differ. 19(3):378-386  

6. Li, X., Wainscott, C., Xi, Y. (2011) MicroRNA provides insight for understanding esophageal cancer. Thoracic Cancer. 2(4): 134-142.  

7. Wang, B., Wang, XF., Xi, Y. (2011) Normalizing bead-based microRNA expression data: a measurement error model-based approach. Bioinformatics. 27(11):1506-1512  

8. Risberg, K., Guldvik, IJ., Palchaudhuri, R., Xi, Y., Ju, J., Fodstad, O., Hergenrother, PJ., Andersson, Y. (2011) Triphenylmethyl derivatives enhances the anticancer effect of immunotoxins. J Immunother. 34(5):438-447.  

9. Kumar, R., Xi, Y. (2011) MicroRNAs, epigenetic machinery, and lung cancer. Thoracic Cancer. 2(2): 35-44  

10. Wang, B., Howell, P., Bruheim, S., Ju, J., Owen, L., Fodstad,O., Xi, Y. (2011) Systematic evaluation of three microRNA profiling platforms: microarray, beads array, and quantitative real-time PCR array. PLoS ONE. 6(2):e17167.

11. Howell, P., Li, X., Riker, AI., Xi, Y. (2010) MicroRNA in Melanoma. Ochsner J. 10(2):83-92.  

12. Wang, B., Wang, XF., Howell, P., Qian, X., Huang, K., Riker, A.l., Ju, J., Xi, Y. (2010) A personalized microRNA microarray normalization method using a logistic regression model. Bioinformatics 26(2): 228-234.

Book: Skin Cancer Overview, Yaguang Xi (Ed.), 2011, ISBN: 978-953-307-746-8, InTech.

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