This lab focuses on the functioning of the tumor cells at the molecular level. Specifically, lab members are interested in understanding how the tumor cells communicate with its surroundings to attain a variety of malignant phenotypes, and if targeting of these tumor-stromal cell interactions could be exploited for cancer prevention and therapy. Another focus is to understand the molecular dissimilarities in tumors from patients of different racial backgrounds and investigate their roles in cancer health disparities.
Ajay P. Singh, Ph.D.: Professor of Oncologic Sciences
Aamir Ahmad, Ph.D.: Research Assistant Professor- Non-coding RNAs, Epigenetics, Signal transduction
Sanjeev Srivastava, Ph.D.: Instructor- Non-coding RNAs, Transcription Factors, Cell Biology
Arun Bhardwaj, Ph.D.: Instructor- Protein phosphatases, Tumor-Microenvironment, Preclinical studies
Haseeb Zubair, Ph.D.: Postdoctoral fellow- Protein kinases, MicroRNAs, Signal transduction
Shafquat Azim, Ph.D.: Postdoctoral fellow- Gene regulation, bioinformatics, Signal transduction
Mohammad Aslam Khan, Ph.D.: Postdoctoral fellow- Tumor-drug interactions, Tumor Microenvironment, Signal transduction
Girijesh Patel, Ph.D.: Postdoctoral fellow- Proteomics, Cell-Cell communication, Exosomes
Courey Averett: Graduate student- Natural products, Cancer prevention and therapy
Mary Patton: Hypoxia, Gene regulation, Exosomes
Small Animal Imaging
5U01CA185490: Molecular determinant of racial disparity in prostate cancer;
Role: Principal Investigator Funding Agency: National Institutes of Health/NCI (U01)
Goal: To investigate the role of Myb and underlying molecular mechanisms in prevalent prostate cancer racial disparity.
5R01CA175772: Targeting Tumor-Stromal Interaction for Pancreatic Cancer Therapy
Role: Principal Investigator
Funding Agency: National Institutes of Health/NCI (R01)
Goal: To investigate the therapeutic significance of targeting CXCL12-CXCR4 and hedgehog pathways in a combination therapy against pancreatic cancer.
MRI1428312: Acquisition of Scanning Transmission Electron Microscope System for Investigation and Characterization of Complex, Nanoscale Systems
Role: Co-Principal Investigator
Funding Agency: National Science Foundation (NSF)
Goal: To acquire transmission electron microscope for shared usage in research and education at the University of South Alabama
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