Thomas W. Butler, M.D.
Senior Staff Medical Oncologist,
Associate Professor of Interdisciplinary Clinical Oncology

USA Mitchell Cancer Institute
1660 Springhill Avenue
Mobile, Alabama 36604
(251) 665-8000

tbutler@health.southalabama.edu

Professional Profile

Clinical Focus:
- Malignancies of the blood, chronic lymphomas, breast cancer, and head and neck cancers

Education:
- B.S., Zoology, University of Tennessee at Martin
- M.D., University of Tennessee Center for the Health Sciences, Memphis
- Residency in Medicine, Erlanger Medical Center, Chattanooga, Tennessee
- Fellow in Hematology/Oncology, University of Alabama at Birmingham

Board Certifications:
- American Board of Internal Medicine, Certification in Internal Medicine
- American Board of Internal Medicine, Certification in Medical Oncology
- American Board of Internal Medicine, Certification in Hematology

Professional Appointments:
- Senior Staff Medical Oncologist, Medical Oncology & Associate Professor, Interdisciplinary Clinical Oncology, USA Mitchell Cancer Institute (2007-present)
- Associate Professor, Department of Internal Medicine & Department of Physician Assistant Studies, University of South Alabama (2008-present)
- Medical Staff, Baptist Hospital, Nashville, Tennessee (2006-2007)
- Medical Staff, Trinity Hospital, Erin, Tennessee (2004-2007)
- Medical Staff, Skyline Medical Center, Nashville, Tennessee (2003-2006)
- Clinical Assistant Professor of Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee (2001-2006)
- Medical Director, Comprehensive Cancer Center Clarksville Memorial Hospital, Clarksville, Tennessee (1993-1997)
- Medical Staff Member, Clarksville Memorial Hospital/Gateway Medical Center, Clarksville, Tennessee (1992-2004)
- Clinical Director of Medical Oncology, Comprehensive Cancer Center Clarksville Memorial Hospital, Clarksville, Tennessee (1992-1997)
- Assistant Professor of Medicine, Department of Medicine, Division of Oncology and Hematology, Texas Tech University Health Sciences Center, Lubbock, Texas (1988-1989)
- Acting Chief, Division of Oncology and Hematology, Texas Tech University Health Services Center, Lubbock, Texas (1988-1989)
- Assistant Professor of Medicine, Section of Hematology/Oncology East Carolina University School of Medicine, Greenville, North Carolina (1988-1989)
- Medical Staff, Skyline Medical Center, Nashville, Tennessee (1988-1989)
- Associate Scientist, Comprehensive Cancer Center, University of Alabama at Birmingham (1987-1988)

Honors and Academic Achievements:
- Coordinator, Multidisciplinary Cancer Conference, University of South Alabama Mitchell Cancer Institute, Mobile, Alabama (2009-present)
- Member, USA Cancer Committee, University of South Alabama, Mobile, Alabama (2008-present)
- Member, Leukemia & Lymphoma Society, Alabama Chapter (2009-present)
- Medical Director, Southern Oncology Specialists (2005-present)
- Member, Cancer Committee, Clarksville Memorial Hospital, Clarksville, Tennessee (2000-2004)
- Medical Director, Clarksville Regional Hematology Oncology Group (CR-HOG) (1996-2006)
- Board Member, Mid South Oncology Associates, Nashville, Tennessee (1997-1998)
- Clinical Teaching Rotation in Hematology Oncology, Gary Chu, MS IV, Meharry Medical School (1997)
- Teaching, Gary Chu, Meharry Medical School, Functioned as a preceptor (1996-1998)
- Member, Vanderbilt Cancer Center Affiliates Network (1996-1997)
- Chairman, Oncology Quality Assessment Committee, Clarksville Memorial Hospital, Clarksville, Tennessee (1995-1996)
- Janice L. Stables, MSN, FNP, OCN, CRNH. One month Oncology Rotation (1995)
- Chairman, Cancer Program Steering Committee, Clarksville Memorial Hospital, Clarksville, Tennessee (1993-1996)
- Member, Cancer Committee, Clarksville Memorial Hospital, Clarksville, Tennessee (1992-1996)
- Chairman, Cancer Committee, Clarksville Memorial Hospital, Clarksville, Tennessee (1992-1996)
- Chairman, Cancer Program Steering Committee, Clarksville Memorial Hospital, Clarksville, Tennessee (1993-1996)
- Member, Ethics Committee, Pitt County Memorial Hospital (1990-1991)
- Member, Department of Medicine Student Committee, East Carolina University School of Medicine (1990-1991)
- East Carolina University, Attending physician on inpatient ward teaching interns, residents and students at ECU School of Medicine (1989-1991)
- Member, Cancer Committee, East Carolina University School of Medicine/Pitt County Memorial Hospital (1989-1991)
- Texas Tech University, School of Medicine Attending physician on inpatient ward and outpatient clinic in the Southwest Cancer Center teaching interns, residents and students (1988-1989)
- Cancer Committee, Texas Tech University Health Sciences Center (1988-1989)
- Subcommittee on Cancer Staging, Lubbock General Hospital/Texas Tech University Health Sciences Center (1988-1989)
- Member, Texas Tech University Health Sciences Center Institutional Review Board (1988-1989)
- Chairman, Cancer Committee, Lubbock General Hospital/Texas Tech University Health Sciences Center (1989)

Professional Memberships:
- Fellow, American College of Physicians
- Member, Tennessee Medical Association
- Member, American Society of Clinical Oncology
- Member, American Society of Hematology
- Member, Mobile Infirmary Cancer Committee
- Member, Department of Internal Medicine, Mobile Infirmary
- Member, Institutional Review Board, University of South Alabama

Grant & Contract Funding:
- USA Center for Healthy Communities, Center of Excellence, Research Core Pilot Grant, “Prospective Study in Psycho-Oncology: Mental Health and Cancer Outcomes in the Underserved Population,” Submitted.
- School of Medicine Starter Grant, East Carolina University School of Medicine, 07/01/91-02/28/92.
- School of Medicine Starter Grant, East Carolina University School of Medicine, 01/01/90-12/31/90.
- School of Medicine Seed Research Grant Program, (Principal Investigator) Texas Tech University Health Sciences Center; Assessment of Monocyte Associated with Lactoferrin in Patients with Chronic Myelogenous Leukemia; Thomas W. Butler, M.D., 09/01/88-08/31/89.
- Clinical Nutrition Research Unit Grant, (Co-Principal Investigator) Department of Nutritional Sciences, University of Alabama at Birmingham: Effects of Dietary Iron on Bleomycin-Induced Pulmonary Fibrosis; David B. Chandler, Ph.D., and Thomas W. Butler, M.D., 06/01/87-06/01/88.
- Walter B. Frommeyer Fellowship, (Principal Investigator) University of Alabama at Birmingham: Quantification of Monocyte Associated Lactoferrin: Thomas Butler, M.D., 07/01/86-07/01/87.

Selected Publications:
1. Butler, T.W., Butler, C., Rhea, W.G. Jr.: IPPB: its effect on postoperative pulmonary complication in a rural hospital. Resp. Therapy 9: 29-32, 1977.

2. Butler, T.W., Feintuch, T.A., Caine, W.P., Jr.: Eosinophilic cholangitis, lymphadenopathy and peripheral eosinophilia: a case report. Am. J. Gastroenterol. 80: 572-574, 1985.

3. Butler, T.W., Gefter, J., Kleto, D., Shuck, E.P. III, Ruffner, B.W.: Squamous cell carcinoma of the anus in condyloma acuminatum: successful treatment in a case using preoperative chemotherapy and radiation. Dis. Colon Rectum 30: 293-295, 1987.

4. Barton, J.C., Parmley, R., Butler, T.W., Williamson, S.W., MacKenzie S, Chandler, D.B., Blackburn, W., Heck, Jr.,L.W.: Neotrophil lactoferrin content: variation among mammals. Anat. Rec. 221: 567-585, 1988.

5. Barton, J.C., Parmley, R., Butler, T.W., Williamson, S., Lilly, M.B., Gualtieri, R.J., Heck, L.W. Jr.: Differential staining of neutrophils and monocytes: surface and cytoplasmic iron-binding proteins. Histochem. J. 20: 147-155, 1988.

6. Chandler, D.B., Barton, J.C., Briggs, D.D., III, Butler, T.W., Kennedy, J.I., Grizzle, W.E., Fulmer, J.D.: Effect of iron deficiency on bleomycin-induced lung fibrosis in hamsters. Am. Rev. Respir. Dis. 137: 85-89, 1988.

7. Chandler, D.B., Butler, T.W., Briggs, D.D., III, Grizzle, W.E., Barton, J.C., Fulmer, J.D.: Modulation of the development of bleomycin-induced pulmonary fibrosis by deferoxamine. Toxicol. Appl. Pharmaco. 92: 358-367, 1988.

8. Butler, T.W., Heck, L.W., Huster, W.J., Grossi, C.E., Barton, J.C.: Assessment of immunoreactive lactoferrin in hematopoietic cells using flow cytometry. J. Immunol. Methods 108: 159-170, 1988.

9. Butler, T.W., Grossi, C.E., Canessa, A., Pistoia, V., Barton, J.C.: Immunoreactive lactoferrin in resting, activated, and neoplastic lymphocytes. Leukemia Research 14: 441-447, 1990.

10. Butler, T.W., Heck, L.W., Berkow, R., Barton, J.C.: Radioimmunometric quantification of surface lactoferrin in blood mononuclear cells. Am. J. Med. Sci. 307(2): 102-107, 1994.

12. von Pawel, Rj., von Roemeling, R., Gatzaemeier, U., Boyer, M., Elisson, L.O., Clark, P., Talbot, D. Rey, A., Butler, T.W., Hirsh, V., Olver, I., Bergman, B., Ayoub, J., Richardson, G., Dunlop D., Arcenas, A., Vescio, R., Viallet, J., Treat J.: Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: a report of the international CTAPUTL I study group. J. Clin, Onc. 18(6): 1351-1359, 2000.

13. Li, X., Zhang, J., Gao, L., McClellan, S., Finan, M.A., Butler, T.W., Owen, L.B., Piazza, G.A., and Xi, Y. MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit. Cell Death Differ. 2012 Mar; 19(3):378-86. doi: 10.1038/cdd.2011.127. Epub 2011 Oct 7. Erratum in: Cell Death Differ. 2012 Mar;19(3):551. PMID: 21979467 [PubMed - indexed for MEDLINE]

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