Ming Tan, M.D., Ph.D.
Chief, Cell Death and Metabolism Research Center
Vincent F. Kilborn, Jr. Cancer Research Scholar
Associate Professor of Oncologic Sciences 

2016-02-26 MCI Ming Tan resized.jpg

USA Mitchell Cancer Institute
1660 Springhill Avenue
Mobile, Alabama 36604
(251) 445-9853
mtan@health.southalabama.edu

Professional Profile

Research Interests

- Metabolism and cancer
- Cell death and stress responsive signaling
- MicroRNA and cancer
- Cancer stem cell
- Cancer metastasis 


Education
 

- Ph.D., University of Texas MD Anderson Cancer Center & Health Science Center, Houston, Texas
- M.D., West China University of Medical Sciences, Chengdu, China
- Fellowship, University of Texas MD Anderson Cancer Center


Professional Appointments

- Associate Professor of Oncologic Sciences, USA Mitchell Cancer Institute (2007-present)
- Graduate Faculty, University of South Alabama Graduate School (2007-present)
- Associate Professor, USA Department of Biochemistry & Molecular Biology (2007-present)
- Research Assistant Professor, University of Texas MD Anderson Cancer Center (2006- 2007)
- Chief, Cell Death and Metabolism Research Center (2011- present)
- Track Leader, USA BMS Cancer Biology Graduate Studies (2013 – present)


Honors and Academic Achievements

- External Advisory Board Member, Cancer Carcinogenesis and Invasiveness Key Lab of the Chinese Ministry of Education (2014- present)
- Guest Professor, Cancer Research Institute, Xiangya Medical School at University of Central South China (2013- present)
- Mayor Mitchell Award for Excellence in Cancer Research, University of South Alabama (2012)
- Vincent F. Kilborn, Jr. Cancer Research Scholar, USA Mitchell Cancer Institute (2007-present)
- Second Prize Winner, Alexander Y-M Wang Memorial Awards, SCBA Annual Scientific Symposium Oral Competition (2003)
- Sowell-Huggins Scholar for Excellence in Cancer Research, The University of Texas MD Anderson Cancer Center and Health Sciences Center at Houston (2000)
- Research Award for Outstanding Young Scientist, Science and Technology Association of Sichuan Province, China (1991)

Professional Memberships:

- American Association for Cancer Research (AACR) 
- American Association for the Advancement of Science (AAAS)
- Metastasis Research Society (MRS)
  

Other Professional Honors / Services:

- Editorial Board, Scientific Report -Nature Publishing Group
- Academic Editor, PLoS ONE 
- Editorial Board: International Journal of Cell Biology
- Editorial Board: World Journal of Biological Chemistry
- Editorial Board: Chemotherapy
- Editorial Board: Journal of Integrative Oncology
- Editorial Board: Cancer Translational Medicine
- Guest Editor for Breast Diseases, Cancer Letters
- Reviewer for Molecular Cell, Cancer Cell, Science Translational Research, Cancer Research, Clinical Cancer Research, Molecular Cancer Therapeutics, Genes, Chromosomes and Cancer, Carcinogenesis, Chemotherapy, Oncogene, Molecular Carcinogenesis, Medical Oncology, British Journal of Cancer, PloS ONE, International Journal of Cell Biology, Journal of Biological Chemistry, and more than 30 scientific journals.
- Scientific Reviewer, DOD Breast Cancer Research Program 2009-2016
- Scientific Reviewer, NIH Tumor Cell Biology (TCB) Study Section, 2012
- Scientific Reviewer, NIH Fellowship: Oncological Sciences (ZRG1 F09) March, 2012-2014
- Scientific Reviewer, Breakthrough Breast Cancer-United Kingdom, 2012
- Scientific Reviewer, Prostate Cancer-United Kingdom, 2013
- Scientific Reviewer, National Research Foundation of Korea (NRF), 2013
- Scientific Reviewer, NIH ZCA1, P01 Program Grant Study Section, 2014
- Scientific Reviewer, NIH ZCA1, R21 R03 Grant Study Section, 2014-2016
- Scientific Reviewer, Natural Science Foundation of China, 2015
- Scientific Reviewer, Israel Science Foundation (ISF), 2015
- Scientific Reviewer, National Science Center of Poland, 2015
- Scientific Reviewer, NIH R01 “Metabolic Reprogramming in Immunotherapy”, 2015-2016
- Reviewer for Molecular Cell, Cancer Cell, Science Translational Research, Cancer Research, Clinical Cancer Research, Molecular Cancer Therapeutics, Genes, Chromosomes and Cancer, Carcinogenesis, Chemotherapy, Oncogene, Molecular Carcinogenesis, Medical Oncology, British Journal of Cancer, PloS ONE, International Journal of Cell Biology, Journal of Biological Chemistry, and more than 30 scientific journals.


Selected Publications

1. S Lim, H Liu, L da Silva, R Arora, Z Liu, JB Phillips, DC Schmitt, T Vu, S McClellan, Y Lin, W Lin, GA Piazza, O Fodstad, and M Tan. (2016) Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α. Cancer Research Published OnlineFirst April 5, 2016

2. Kim JH,  Baddoo MC, Park EY, Stone JK, Park H, Butler TW, Huang G, Yan X, Pauli-Behn F, Myers RM, Tan M, Flemington EK, Lim ST, Ahn EY.   (2016)  SON and its alternatively spliced isoforms control MLL complex-mediated H3K4me3 and transcription of leukemia-associated genes. Molecular Cell 61:859-873

3. Klionsky, D.J; Zughaier S.M. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1), 1-222.

4. Yuzefovych LV, Kahn AG, Schuler MA, Eide L, Arora R, Wilson GL, Tan M, Rachek LI. (2016) Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis. Cancer Research 76(1):30-4.

5. Schmitt DC, Madeira da Silva L, Zhang W, Liu Z, Arora R, Lim S, Schuler AM, McClellan S, Andrews JF, Kahn AG, Zhou M, Ahn EY, Tan M. (2015) ErbB2-intronic microRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling. Cell Death Dis. 6:e1742

6. Butler, E.B., Zhao, Y., Muñoz Pinedo, C., Lu, J., and Tan, M. (2013) Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance (Invited Review). Cancer Research 73(9):2709-17.

7. Desai S, Liu Z, Yao J, Patel N, Chen J, Wu Y, Ahn EE, Fodstad O, Tan M. (2013) Heat Shock Factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of Autophagy -related Protein 7 (ATG7). J. Biol. Chem. 288(13):9165-76.

8. Yuhua Zhao, Ethan B. Butler, and Ming Tan. (2013) Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis.  4:e532.

9. Zixing Liu, Hao Liu, Shruti Desai, David Schmitt, Hung T. Khong, Kristine S. Klos, Steven McClellan, Oystein Fodstad, and Ming Tan. (2013) Upregulation of MicroRNA-125b through Wnt signaling by Snail Enriches Cancer Stem Cells and Increases Chemoresistance.  J. Biol. Chem., 288(6):4334-45.

10. Kamarajugadda S, Stemboroski L, Cai Q, Simpson NE, Nayak S, Tan M, Lu JR. (2012) Glucose Oxidation Modulates Anoikis and Tumor Metastasis. Mol. Cell. Biol. 32:1893-907.

11. Zhao Y, Liu H, Liu Z, Ding Y, LeDoux SP, Wilson GL, Voellmy R, Lin Y, Lin W, Nahta R, Liu B, Fodstad O, Chen J, Wu Y, Price JE, and Tan M. (2011) Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism. Cancer Research 71: 4585-97.

12. Zhao YH, Zhou M, Liu H, Ding Y, Khong HT, Yu DH, Fodstad O, and Tan M. (2009) Upregulation of LDH-A by ErbB2 through HSF1 promotes breast cancer cell glycolysis and growth. Oncogene 42: 3689–3701.

13. Zhou M, Liu ZX, Zhao YH, Ding Y, Liu H, Xi Y, Xiong W, Li GY, Lu J, Fodstad O, Riker AI, and Tan M. (2010) MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1). J. Biol. Chem. 285: 21496-21507.

14. Nagata Y, Lan KH, Zhou X, Tan M, Esteva FJ, Sahin AA, Klos KS, Li P, Monia BP, Nguyen NT, Hortobagyi GN, Hung MC, and Yu D. (2004) PTEN Activation Contributes to Tumor Inhibition by Trastuzumab and Loss of PTEN Predicts Trastuzumab Resistance in Patients. Cancer Cell, 6:117-21, 2004

15. Tan M, Jing T, Lee S, Lan KH, Li P, Nagata Y, Liu J, Arlinghaus R, Hung MC, and Yu D. (2002) Direct Phosphorylation on Tyrosine-15 of p34Cdc2 by erbB2 Receptor Tyrosine Kinase Inhibits p34Cdc2 Activation. Molecular Cell, 9:993-1004, 2002. 




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