Chemoprevention and Experimental Therapeutics
Chief: Gary Piazza, Ph.D.
- Dedicated medicinal chemistry effort focused on the synthesis of novel compounds with potential for highly selective anti-cancer activity to treat or prevent cancer.
- Cellular and biochemical research aimed at target validation and defining critical cellular pathways for selective killing of cancer cells.
- Pre-clinical pharmacology studies to evaluate safety and efficacy of experimental anti-cancer drugs.
- Focus on colon, breast, ovarian, pancreatic and lung cancer
- Novel Ras inhibitor class as a prospective clinical candidate for the treatment of Ras-driven cancers
Molecular and Metabolic Oncology
Chief: Robert W. Sobol, Ph.D.
Focus: Cellular mechanisms of DNA repair, DNA damage response and DNA metabolism and how these processes impact cancer development and the response to cancer treatments.
- DNA repair
- DNA damage response
- DNA damage/repair – impact on cellular metabolism
- Chemo/radiation response ó DNA repair capacity
- Oxidative damage / oxidative stress
- Structural biology of DNA repair complexes
- Chemical biology of ADP-ribose biosynthesis enzymes
- Regulation of DNA repair by ubiquitylation
Chief: Position available
- Cancer Cell Metabolism and Energetics
- Cancer Stem Cells
- Cancer Biomarkers in Detection and Progression
- Molecular Mechanisms Involved in Cancer Progression
Overarching Theme: Molecular Mechanisms Underlying Cancer Health Disparities
Cancer Control and Prevention
Director: Margaret Sullivan, MS
Mission: To reduce the risk, incidence and mortality from cancer and enhance the quality of life of cancer survivors
- Prevention and Early Detection (Colorectal, Skin, Breast, Cervical, Lung)
- Value-Based Oncology Care and Health Services Delivery Research