Komaraiah Palle, Ph.D. (Kumar)
Abraham Mitchell Cancer Research Scholar, Assistant Professor of Oncologic Sciences

2016-03-09 MCI Kumar Palle.jpg

USA Mitchell Cancer Institute
1660 Springhill Avenue
Mobile, Alabama 36604
(251) 445-9854
kpalle@health.southalabama.edu


 Professional Profile

 Research Interests

- Molecular carcinogenesis mechanisms
- Genome instability syndromes (Fanconi anemia and BRCA genes)
- Ubiquitin ligases and their role in DNA damage response and repair
- Cell cycle regulation and DNA replication
- DNA topoisomerases and their inhibitors 
- Hedgehog/Gli1 signaling
- Epigenetic mechanisms in regulation of cell cycle and DNA repair
- Molecular cancer therapeutics
- Mechanistic studies on natural and dietary compounds

Education 
- B.S., Biology & Chemistry, Kakatiya University, India (1994)
- M.S., Biotechnology, Acharya Nagarjuna University, India (1996)
- Ph.D., Genetics, Osmania University, India (2003)
- Visiting Scientist- (Carl-Triggers Fellowship)-Linkoeping University, Sweden (2002-2003)
- Postdoctoral Fellowship- St. Jude Children’s Research Hospital, Memphis, Tenn. (2003-2009)

Professional Appointments
- Assistant Professor - Department of Oncologic Sciences, USA Mitchell Cancer Institute, Mobile, Ala., USA (2012-Present)
- Abraham Mitchell Cancer Research Scholar, USA Mitchell Cancer Institute, Mobile, Ala. (2012-Present)
- Assistant Professor (Adjunct) Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, Ala., USA (2013-Present)
- Member Graduate Faculty, University of South Alabama (2013-present)
- Research Associate/ Assistant Professor -  Department of Pathology and Lab Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C., (2009 – 2012)

Professional Honors and Awards

- Senior Research Fellowship from Department of Biotechnology, Ministry of Science and Technology, Government of India (1999-2002).
- First prize for the best presentation in BIOHORIZON2001, 3rd National Symposium in Biochemical Engineering & Biotechnology, February 23-24 at Indian Institute of Technology, Delhi (2001)
- Carl-Triggers Foundation Visiting Scholar Fellowship, Linkoeping University, Linkoeping, Sweden (2002-2003)
- Travel Grant to Young Investigators Meeting 2011, India
- Abraham Mitchell Cancer Research Scholar  (2012)

Selected Publications

  1. Kothayer H,  Spencer S, Tripathi K, Westwell AD and Palle K (2016) Synthesis and in vitro anticancer evaluation of some 4,6-diamino1,3,5triazine-2-carbohydrazides as Rad6 Ubiquitin conjugating enzyme inhibitors. Bioorganic and Medicinal Chemistry Letters 26(8):2030-4. PMID: 26965855; PMCID: PMC4808444
  2. Tripathi k, Mani C, Clark D, Barnett R, Palle K (2016) Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery. Oncotarget. (Epub ahead of print). PMID: 26871286
  3. Rani V, Deep G, Singh RK and Palle K, Yadav UCS (2016) Oxidative Stress in Metabolic   Disorders: Pathogenesis, Prevention, and Therapeutics. Life Sciences. S0024-3205(16)30052-2; PMID: 26851532 (Invited review).
  4. Somasagara RS, Tripathi K, Spencer SM, Clark DW, Barnett R, Bachaboina L, Scalici J, Rocconi RP, Piazza GA, Palle K (2016) Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer. Biochem Biophy Res Commun. 469, 449-455. PMID: 26679603; PMCID: PMC4715924
  5. Clark DW, Tripathi K, Dorsman JC and Palle K (2015) FANCJ deficiency compromises the stability of FANCD2/FANCI complex and promotes their degradation in a Caspase-3 mediated mechanism. Oncotarget, 6 (30); 28816-32.  PMID:26336824
  6. Palle K*, Mani C, Tripathi K and Athar M.  (2015) Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance. Cancers, 7, 2330-2352. (invited review), PMID: 26633513; PMCID: PMC4695894
  7. Tripathi K, Hussein UK, Anupalli R, Barnett R, Bachaboina L, Scalici J, Rodney RP, Owen LB, Piazza GA and Palle K (2015) Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation. Oncotarget 10;6(7):5237-52; PMID: PMID:25742788; PMCID: PMC4467145
  8. Srivastava RK, Kaylani SZ, Nayf Edrees, Li C, Talwelkar SS, Xu J, Palle K, Pressey JG, Mohammad Athar (2014)  GLI inhibitor GANT-61 diminishes rhabdomyosarcoma (RMS) growth and aggressive tumor phenotype by targeting proliferation and epithelial mesenchymal transition. Oncotarget 5(23):12151-65; PMID: 25432075; PMCID:PMC4322980
  9. Tripathi K, Mani C, Barnett R, Nalluri S, Bachaboina L, Rocconi RP, Athar A,  Owen LB,  Palle K (2014) Gli1 regulates S-phase checkpoint in tumor cells via Bid and its inhibition sensitizes them to DNA topoisomerase 1 inhibitors. Journal of Biological Chemistry 289(45):31513-25. PMID: 25253693; PMCID: PMC4223349
  10. Meng E, Mitra A, Tripathi K, Finan MA, Scalici J,  McClellan S, Reed E, Shevde LA, Palle K*, Rocconi RP * (2014).  ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling, PLoS One 9(9):e107142. (* Co-corresponding authors). PMID:25216266; PMCID:PMC4162571This article was highlighted in the Cancer Stem Cell News. http://www.cancerstemcellnews.com/issue/volume-3-36-sep-17/
  11. Barkley LR*, Palle K*, Durando M*, Day TA, Gurkar A,  Kakusho Masai NH, Vaziri C (2012) c-Jun     N-terminal Kinase (JNK)-Mediated Rad18 Phosphorylation Facilitates Recruitment of Pol??to Stalled Replication Forks. Mol Biol Cell. 23(10):1943-54; PMID: 22456510; PMCID: PMC3350557
  12. Palle K*, Vaziri C (2011). Rad18-mediated activation of fanconi anemia pathway in response   to Top1 inhibitor camptothecin.  Cell Cycle 10(10): 1625-38; PMID: 21478670; PMCID: PMC3127162 (*corresponding author). Selected for featuring in News and Views. Written by Dr. Anindya Dutta (University of Virginia) and Dr. Satoshi Tateishi (Kumamoto University, Japan.
  13. Day T, Palle K, Barkley LR, Yoshizawa-Sugata N,  Zou Y,  Tateishi S, Verreault A, Masai H, Vaziri C. (2010) Cdc7-mediated posphorylation of Rad18 directs the accumulation of DNA polymerase eta at sites of stalled replication. Journal of Cell Biology 191(5):953-66; PMID: 21098111; PMCID: PMC299517
  14. Song IY*, Palle K*, Gurkar A, Tateishi S, Kupfer GM and Vaziri C (2010) Rad18-mediated trans-lesion synthesis of bulky DNA adducts is coupled to activation of the fanconi anemia DNA repair pathway. Journal of Biological Chemistry 285:31525-36; PMID: 20675655; PMCID: PMC2951227 (*contributed equally).
  15. Palle K, Pattarello L, van der Merwe M, Benedetti P, Bjornsti M-A (2008) Disulfide crosslinks reveal conserved features of DNA topoisomerase I architecture and a role for the N-terminus in clamp closure. Journal of Biological Chemistry 283: 27767-75, PMID: 18693244. PMCID: PMC2562070
  16. Koster DA, Palle K, Bot ESM, Bjornsti M-A, Dekker NH (2007)  “Antitumor drugs impede DNA uncoiling by Topoisomerase I”, Nature 448: 213-7; PMID: 17589503. (with cover illustration) and Research comment highlighted, Nature Structural & Molecular Biology   14:688, 2007). Featured in Nature Podcasts and many national and international news.
  17. Koster DA, Czerwinski F, Halby L, Crut A, Vekhoff P, Palle K, Arimondo P, Dekker NH (2008) Single-molecule observations of topotecan-mediated TopIB activity at a unique DNA sequence. Nucleic Acids Research 36: 2301-10; PMID: 18292117; PMCID: PMC2367732
  18. Montaudon D*, Palle K*, Rivory LP, Robert J, Douat-Casassus C, Quideau S, Bjornsti M-A, Pourquier P (2007) Inhibition of Topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505. Journal of Biological Chemistry 282: 14403-12;   PMID: 17355975.  (*Contributed equally).
  19. Losasso C, Cretario E, Palle K, Pattarello L, Bjornsti M-A, Benedetti P (2007) Alterations in linker flexibility suppress DNA Topoisomerase I mutant-induced cell lethality. Journal of Biological Chemistry 282: 9855-64; PMID: 17276985.
  20. Komaraiah P, Kavi Kishor P.B., Carlsson M, Magnusson KE, Mandenius CF (2005) Enhancement of anthraquinone accumulation in Morinda citrifolia suspension cultures. Plant Science 168: 1337-44.
  21. Komaraiah P, Navratil M, Carlsson M, Jeffers P, Brodelius M, Brodelius PE, Kieran PM, Mandenius CF. (2004) Growth behavior in plant cell cultures based on emissions detected by a multi-sensor array. Biotechnol Prog  20:1245-50; PMID: 15296455.
  22. Komaraiah P, Reddy GV, ReddyPS, Raghavendra AS, Ramakrishna SV, Reddanna P (2003) Elicitor induced enhanced production of antimicrobial sesquiterpenes and lipoxygenase metabolites from potato hairy root cultures. Biotechnology Lett 25: 593-97.

 

 

 

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