Adam B. Keeton, Ph.D.

Research Assistant Professor of Oncologic Sciences

2016-02-26 MCI Adam Keaton resized.jpg


USA Mitchell Cancer Institute
1660 Springhill Avenue
Mobile, Alabama 36604
(251) 445-8413


Professional Profile

Research Interests:
- Cancer chemoprevention and anti-cancer drug discovery
- High Content and High Throughput Screening
- Assay Development for Laboratory Automation

- B.S., Natural Sciences, University of Alabama at Birmingham
- Ph.D., Pathology, University of Alabama at Birmingham
- Postdoctoral Fellowships, University of Alabama at Birmingham and Southern Research Institute

Professional Appointments:
- Research Assistant Professor of Oncologic Sciences, Drug Discovery, USA Mitchell Cancer Institute (2011-present)
- Research Biologist; Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute (2010-2011)
- Associate Research Biologist; Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute (2006-2010)

Professional Memberships:
- American Association for Cancer Research
- Society for Laboratory Automation and Screening
- American Society of Pharmacology & Experimental Therapeutics

Selected Publications:
1. Tinsley HN, Gary BD, Keeton AB, Lu W, Li Y, Piazza GA. 2011. Inhibition of PDE5 by Sulindac Sulfide Selectively Induces Apoptosis and Attenuates Oncogenic Wnt/{beta}-Catenin-Mediated Transcription in Human Breast Tumor Cells.. Cancer Prev Res;4(8):1275-84. 

2. Li HF, Keeton A, Vitolo M, Maddox C, Rasmussen L, Hobrath J, White EL, Park BH, Piazza G, Kim JS, Waldman T. 2011 A High-Throughput Screen with Isogenic PTEN+/+ and PTEN-/- Cells Identifies CID1340132 as a Novel Compound That Induces Apoptosis in PTEN and PIK3CA Mutant Human Cancer Cells.J Biomol Screen. 16(4):383-93. 

3. Bortoff KD, Keeton AB, Franklin JL, Messina JL. 2010 Anti-Inflammatory Action of Insulin via Induction of Gadd45-ß Transcription by the mTOR Signaling Pathway. Hepat Med 2001(2):79-85. 

4. Tinsley HN, Gary BD, Thaiparambil J, Li N, Lu W, Li Y, Maxuitenko YY, Keeton AB, Piazza GA. 2010 Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition. Cancer Prev Res. 3(10):1303-13. 

5. Gabriela Chiosis and Adam B. Keeton. 2009. Assay for Isolation of Inhibitors of Her2-Kinase. Methods of Molecular Biology: Cell-Based Assays for High-Throughput Screening, 486: 139-149. 

6. Tinsley HN, Gary BD, Keeton AB, Zhang W, Abadi AH, Reynolds RC, Piazza GA. 2009 Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G. Mol Cancer Ther. 8(12):3331-40. 

7. Abadi AH, Abouel-Ella DA, Ahmed NS, Gary BD, Thaiparambil JT, Tinsley HN, Keeton AB, Piazza GA. 2009. Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents. Arzneimittelforschung, 59(8):415-21. 

8. Piazza GA, Keeton AB, Tinsley HN, Gary BD, Whitt JD, Mathew B, Thaiparambil J, Coward L, Gorman G, Li Y, Sani B, Hobrath JV, Maxuitenko YY, Reynolds RC. 2009. A Novel Sulindac Derivative That Does Not Inhibit Cyclooxygenases but Potently Inhibits Colon Tumor Cell Growth and Induces Apoptosis with Antitumor Activity. Cancer Prev Res, 2(6):572-80. 

9. Franklin JL, Keeton AB, Bortoff KD, Messina JL. 2008. Insulin Dependant Gene Expression of Heat Shock Protein 60 in H4IIE Hepatoma Cells. Int J Clin Exp Med, 1(1):89-97. 

10. Lu, W, Tinsley, HN, Keeton A, Qu Z, Piazza GA, Li Y. 2009. Suppression of Wnt/beta-catenin Signaling Inhibitors Prostate Cancer Cell Proliferation. Eur. J. Pharmacol, 603:8-14. 

11. WL Bennett, AB Keeton, S Ji, J Xu, JL Messina. 2007. Insulin regulation of growth hormone receptor gene expression: involvement of both the PI-3 kinase and MEK/ERK signaling pathways. Endocrine, 32(2):219-26. 

12. J. Xu, A.B. Keeton, J.L. Franklin, X. Li, D.Y. Venable, S.J. Frank and J.L. Messina. 2006. Insulin Enhances Growth Hormone Induction of the MEK/ERK Signaling Pathway. Journal of Biological Chemistry, 281: 982-992. 

13. A.B. Keeton, K.D. Bortoff, J.L. Franklin and J.L. Messina 2005. Blockade of rapid versus prolonged ERK1/2 activation has differential effects on insulin-induced gene expression. Endocrinology, 146(6):2716-25. 

14. J. Xu, A.B. Keeton and J.L. Messina 2005. Gene 33: a Proliferation-Associated Gene Regulated by EGF and Retinoic Acid in Breast Cancer Cell-Lines. Breast Cancer Research and Treatment, 91(3):207-15. 

15. A.B. Keeton and J.L. Messina 2005. Messina. Modulation of Elk-dependent-transcription by Gene33. Journal of Cellular Biochemistry 94(6):1190-8.


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