Environmental Modulation of DNA Repair

 

Focus

Applying interdisciplinary research techniques in molecular biology, toxicology, and biophysics to examine the gene-environment interactions of endocrine-disrupting chemical exposure. Understanding the underlying mechanisms modulating DNA damage response and repair will provide insight into future therapeutic intervention for EDC-exposed individuals.

 

Gassman cell resized.jpgFaculty and staff

Natalie R. Gassman, Ph.D.: Assistant Professor of Oncologic Sciences
Nathaniel Holton, Ph.D.: Postdoctoral fellow-DNA damage signaling and repair
Varsha Pednekar, Ph.D.: Postdoctoral fellow-Environmental toxicology and DNA repair

 

Projects

  • Modulation of DNA damage response and repair pathways by environmental chemicals
  • Micro-irradiation techniques to monitor the recruitment of single strand break and base excision repair proteins to sites of DNA damage
  • Alterations in the repair of oxidatively-induced DNA lesions by chromatin structure

 

gassman model 2.jpg

Micro-irradiation induces site-specific DNA damage that can be used to monitor the recruitment of DNA repair proteins. Adapted from Gassman et al. DNA Repair 2015.

 

Core Labs

Cellular and Biomolecular Imaging

 

Funding

Current:

R00ES023813 Bisphenol A modulation of DNA repair triggered by environmental stress

 

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