DNA Damage and Repair Lab



Research in the Sobol lab focuses on the mechanism of base excision repair, PARP and NAD+ metabolism in human cells and the convergent role of these enzymes and pathways in response to environmental Genotoxins and chemotherapy. A major goal in the lab is to use biochemical, genetic and imaging modalities to study the protein complexes of the base excision repair pathway that respond to DNA damage induced by Genotoxins and chemotherapy and how this pathway affects the regulation of cellular metabolism via ADP-ribosylation signaling and alterations in NAD+ metabolism. 


2016-02-04 Robert Sobol MCI MK4 resized.jpgFaculty and Staff

Robert W. Sobol, Ph.D.
Lab chief

Anna Wilk

Peter Sykora, Ph.D.

Jennifer Clark, Ph.D.
Research Associate I

Jianfeng Li, Ph.D.
Research Assistant Professor

Qingming Fang, Ph.D.
Research Assistant Professor

Joel Andrews, Ph.D.
Research Assistant Professor

Leila Zamani
Research Assistant I

Lavania Bachaboina
Research Assistant I


Core labs

Cellular and Biomolecular Imaging

GEED Facility

Protein (recombinant) Expression and Purification Facility

Technology Development Facility



The Sobol lab has been continually funded by grants from NIH (NCI) as well as those from the American Cancer Society, the Susan G. Komen Breast Cancer Foundation, the Brain Tumor Society, the Pittsburgh Foundation and the Elsa U. Pardee Foundation for Cancer Research, among others.


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