University of South Alabama

Research in Progress

Every Tuesday, 11:00 - 12:00 a.m.
3rd Floor Conference Room - MSB 3360


Topics and Speakers for 2014

May 13, 2014, Ashley Lindsey
Tissue-Engineered Lungs for in Vivo Implantation
Thomas H. Petersen et al. Science 329, 538 (2010); DOI: 10.1126/science.1189345

May 6, 2014, Kathleen McClinton
Secretome of Transmissible Pseudomonas aeruginosa AES-1R Grown in a Cystic Fibrosis Lung-Like Environment | J. Proteome Res. 2013, 12, 5357−5369

Apr. 8, 2014, Audrey Vasauskas
FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential
Cell Death and Disease (2013) 4, e578; doi:10.1038/cddis.2013.109

Mar. 25, 2014, Adam Morrow
Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells
H. Bähre et al., Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells, Biochem. Biophys. Res. Commun. (2014),

Mar. 18, 2014, Ningyong Xu
Role of molecular determinants of store-operated Ca 2+ entry (Orai1, phospholipase A2 group 6 and STIM1) in focal adhesion formation and cell migration.
J. Biol. Chem. published online October 5, 2012. doi: 10.1074/jbc.M112.407155

Mar. 11, 2014, Leslie Hargett
Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner
Blood. 2011 Aug 25;118(8):2366-74. doi: 10.1182/blood-2011-01-330878. Epub 2011 Jun 23.

Feb. 25, 2014, Jamie Kuck
Alveolar macrophages mediate release of mtDNA DAMPs in Pseudomonas aeruginosa-challenged rat lungs

Feb. 18, 2014, Ed Crockett
Comparison of Neutron Activated and Radiolabeled Microsphere Methods for Measurement of Transmural Myocardial Blood Flow in Dogs
Journal of Thrombosis and Thrombolysis 19(3), 201–208, 2005.

Feb. 11, 2014, Kaori Oshima
Understanding the Pathogenesis of Plexiform Lesions in PAH

Feb. 4, 2014, Victor Solodushko
Novel minimal piggyBac vectors for safe and stable gene delivery

Jan. 28, 2014, Adam Morrow
Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells
H. Bähre et al., Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells, Biochem. Biophys. Res. Commun. (2014),

Jan. 14, 2014, Chun Zhou
Impairment of Store-Operated Ca2+ Entry in TRPC4-/- Mice Interferes With Increase in Lung Microvascular Permeability
Circ Res. 2002;91:70-76; doi: 10.1161/01.RES.0000023391.40106.A8


Previous Years

Dec. 10, 2013, Thomas Yarbrough
Induction of pulmonary hypertension changes by extracellular vesicles from monocrotaline-treated mice
Cardiovascular Research. doi:10.1093/cvr/cvt184
Nov. 19, 2013, Rebecca Morrow
Dominant Suppression of Inflammation by Glycan-hydrolized IgG
PNAS 110(25): 10252-7.  doi:10.1073/pnas.1301480110
Nov. 12, 2013, Chian Ju Jong
Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma Cells
PLoS ONE 7(6): e38706. doi:10.1371/journal.pone.0038706
Nov. 05, 2013, Jared McLendon
Pulmonary Arterial Hypertension Is Linked to Insulin Resistance and Reversed by Peroxisome Proliferator–Activated Receptor-γ Activation
Circulation 2007;115:1275-84; doi: 10.1161/CIRCULATIONAHA.106.663120
Oct. 29, 2013, Naga Annamdevula
An Approach for Characterizing and Comparing Hyperspectral Microscopy Systems
Sensors 2013, 13, 9267-9293; doi:10.3390/s130709267
Oct. 22, 2013, Jim Parker
Non–Muscle Myosin Light Chain Kinase Isoform Is a Viable Molecular Target in Acute Inflammatory Lung Injury
Am J Respir Cell Mol Biol Vol 44. pp 40–52, 2011; doi: 10.1165/rcmb.2009-0197OC
Oct. 15, 2013, Andrew Ferretti
Multiple Checkpoint Breach of B Cell Tolerance in Rasgrp1-Deficient Mice
 Immunol 2013; 191:3605-3613; doi: 10.4049/jimmunol.1202892
Sep. 24, 2013, Patricia Villalta
TRPV4-Mediated Calcium Influx into Human Bronchial Epithelia upon Exposure to Diesel Exhaust Particles
Environ Health Perspect 119:784-93, Jun 2011; doi:10.1289/
Sep. 17, 2013, Mark Taylor
"Calcium dynamics and functional tuning of the vascular endothelium"
No article
Sep. 10, 2013, Peter Favreau
Thin-film Tunable Filters for Hyperspectral Fluorescence Microscopy
Sep. 3, 2013, Troy Stevens
Trans-cellular Propagation of Tau Aggregation by Fibrillar Species
J Biol Chem 2012, 287:19440-19451; doi: 10.1074/jbc.M112.346072
Aug. 27, 2013, Mary Townsley
Mechanisms of Signal Transduction: Mitochondria Efficiently Buffer Subplasmalemmal Ca 2+Elevation during Agonist Stimulation
J Biol Chem 2003, 278:10807-10815; doi: 10.1074/jbc.M212971200
Aug. 20, 2013, Salina Gairhe
Targeting sphingosine kinase 1 attenuates bleomycininduced pulmonary fibrosis
FASEB J, Vol 27, April 2013; doi: 10.1096/fj.12-219634 
Jun. 04, 2013, Pierre Kadeba
The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress
The Journal of Biological Chemistry, Vol 286, Number 34, August 26, 2011
May 28, 2013, Kaori Oshima
The role of disturbed blood flow in the development of Pulmonary Arterial Hypertension: Lessons from preclinical animal models
Am J Physiol Lung Cell Mol Physiol, 26 April 2013; doi: 10.1152/ajplung.00031.2013
May 14, 2013, Kathleen McClinton
Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity
SCIENCE, Vol 340, 5 April 2013; doi: 10.1126/science.1232552
May 07, 2013, Leslie Hargett
"Do microparticles promote endothelial cell adhesion in pulmonary arterial hypertension?"
No article
Apr. 30, 2013, Terrance Platt
Prolonged vasoconstriction of resistance arteries involves vascular smooth muscle actin polymerization leading to inward remodeling
Cardiovasc Res 2013; doi: 10.1093/cvr/cvt034
Apr. 16, 2013, Rebekah Morrow
Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation
SCIENCE, Vol 313, 4 August 2006; doi: 10.1126/science.1129594
Apr. 09, 2013, Ashley DeCoux
TLR signaling prevents hyperoxia-induced lung injury by protecting the alveolar epithelium from oxidant-mediated death
J Immunol 2012, 189:356-364; doi: 10.4049/jimmunol.1103124
Apr. 02, 2013, Jamie Hill
Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways
PLOS ONE, Vol 8, Issue 3, March 2013; doi:10.1371/journal.pone.0059989
Mar. 26, 2013, Thomas Yarbrough
Microparticles induce cell cycle arrest through redox-sensitive processes in endothelial cells: Implications in vascular senescence
J Am Heart Assoc 2012, 1; doi: 10.1161/JAHA.112.001842
Feb. 26, 2013, Ningyong Xu
Transient receptor potential canonical channels are required for in vitro endothelial tube formation
The Journal of Biological Chemistry, Vol 287, Number 8, February 17, 2012
Feb. 05, 2013, Adam Morrow
Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
Scientific Reports, Oct. 3, 2012
Jan. 29, 2013, Phoibe Renema
Pseudomonas aeruginosa selective adherence to and entry into human endothelial cells
Infection and Immunity, Vol 62, Number 12, Dec. 1994
Jan. 22, 2013, Ed Crockett
Targeted gene delivery of BMPR2 attenuates pulmonary hypertension
European Respiratory Journal, Vol 39, Number 2, 2012
Jan. 15, 2013, Joshua Phillips
The role of the microtubules in tumor necrosis factor-α–induced endothelial cell permeability
American Journal of Respiratory Cell and Molecular Biology, Vol 28, 2003
Jan. 08, 2013, Kari Dugger
Inhibition of cAMP degradation improves regulatory T cell-mediated suppression
The Journal of Immunology, 2009, 182: 4017– 4024
Dec. 11, 2012, Kealan O’Neill
Coordination of fibronectin adhesion with contraction and relaxation in microvascular smooth muscle
Cardiovascular Research (2012) 96, 73–80
Dec. 04, 2012, Patricia Villalta
The history of matrix metalloproteinases: milestones, myths, and misperceptions
Am J Physiol Heart Circ Physiol 303: H919–H930, 2012
Nov. 27, 2012, Audrey Vasauskas
Local cytosolic Ca2+ elevations are required for stromal interaction molecule 1 (STIM1) de-oligomerization and termination of store-operated Ca2+ entry*
Journal of Biological Chemistry, Vol 286, Number 42, October 21, 2011
Nov. 13, 2012, Luai Hasoun
Human skin pigmentation as an adaptation to UV radiation
PNAS, Vol 107, Suppl 2, May 10, 2010
Oct. 30, 2012, Dr. Mark Gillespie
Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation
New England Journal of Medicine, 364; 15, April 14, 2011
Oct. 23, 2012, Ashley Stringfellow
Maintenance and Repair of the Lung Endothelium Does Not Involve Contributions from Marrow-Derived Endothelial Precursor Cells
American Journal of Respiratory Cell and Molecular Biology, Vol 47, 2012
Oct. 16, 2012, Andrew Ferretti
T cells become licensed in the lung to enter the central nervous system
Nature, Vol 488, August 30, 2012
Oct. 09, 2012, Kealan O’Neill
Coordination of fibronectin adhesion with contraction and relaxation in microvascular smooth muscle
Cardiovascular Research (2012) 96, 73–80
Sept. 18, 2012, Jared McLendon
A Role for miR-145 in Pulmonary Arterial Hypertension Evidence From Mouse Models and Patient Samples
Circulation Research, July 20, 2012
Sept. 04, 2012, Peter Favreau
Spectral Imaging: Principles and Applications
International Society for Analytical Cytology Cytometry Part A 69A:735–747 (2006)
Aug. 21, 2012, Abdallah Alzoubi
Modern age pathology of pulmonary arterial hypertension
American Journal of Respiratory and Critical Care Medicine, Vol 186, 2012
May 15, 2012, Ed Crockett
Sialic acids attached to O-Glycans modulate voltage-gated potassium channel gating
Journal of Biological Chemistry, Vol 286, Number 6, February 11, 2011
May 01, 2012, Heba Khader
The roles of hyperglycaemia and oxidative stress in the rise and collapse of the natural protective mechanism against vascular endothelial cell dysfunction in diabetes
Archives of Physiology and Biochemistry, October/December 2007; 113(4/5): 259 – 267
Apr. 10, 2012, Pierre Kadeba
Control of glucocorticoid and progesterone receptor subcellular localization by the ligand-binding domain is mediated by distinct interactions with tetratricopeptide repeat proteins
Biochemistry. 2008 September 30; 47(39): 10471–10480. doi:10.1021/bi8011862.
Apr. 03, 2012, Jamie Hill
Mitochondrial damage associated molecular patterns from femoral reamings activate neutrophils through formyl peptide receptors and P44/42 MAP kinase
J Orthop Trauma, Vol 24, Number 9, September 2010
Mar. 27, 2012, Chian Ju Jong
Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease
PNAS, October 19, 2004, Vol 101, Number 42, 15073
Mar. 20, 2012, Leslie Hargett
Circulating Microparticles from Pulmonary Hypertensive Rats Induce Endothelial Dysfunction
American Journal of Respiratory and Critical Care Medicine, Vol 182, 2010
Mar. 05, 2012, Ashley DeCoux
Lipopolysaccharide Disrupts the Directional Persistence of Alveolar Myofibroblast Migration through EGF Receptor
Am J Physiol Lung Cell Mol Physiol (January 13, 2012)
Feb. 28, 2012, Cristhiaan Ochoa
Aberrant Tau Phosphorylation by Glycogen Synthase Kinase-3 and JNK3 Induces Oligomeric Tau Fibrils in COS-7 Cells*
The Journal of Biological Chemistry, Vol 277, Number 44, November 1, 2002, pp. 42060–42065
Tau Aggregation and Toxicity in a Cell Culture Model of Tauopathy*
The Journal of Biological Chemistry, Vol 282, Number 22, June 1, 2007, pp. 16454–16464
Feb. 14, 2012, Terrance Platt
The Effects of the Small GTPase RhoA on the Muscarinic Contraction of Airway Smooth Muscle Result from Its Role in Regulating Actin Polymerization
Am J Physiol Cell Physiol 299: C298–C306, 2010
Feb. 07, 2012, Ningyong Xu
Plasma Sodium Stiffens Vascular Endothelium and Reduces Nitric Oxide Release
PNAS  Oct. 9, 2007  Vol. 104  No. 41  16281–16286
Dec. 06, 2011, Patricia Villalta
TRPV4 Channels Augment Macrophage Activation and Ventilator-induced Lung Injury
Am J Physiol Lung Cell Mol Physiol 299: L353–L362, 2010
Nov. 29, 2011, Rebekah Morrow
Fcγ R-stimulated Activation of the NADPH Oxidase: Phosphoinositide-binding Protein p40phox Regulates NADPH Oxidase Activity after Enzyme Assembly on the Phagosome
Blood, 1 Nov. 2008, Vol. 112, Number 9
Nov. 22, 2011, Jared McLendon
Role for miR-204 in Human Pulmonary Arterial Hypertension
J. Exp. Med Published February 14, 2011
Nov. 08, 2011, Courtney R. Ochoa
Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization
Cell 147, 539–553, October 28, 2011
Nov. 01, 2011, Ashley Stringfellow
Peripheral Infusion of Rat Bone marrow Derived Endothelial Progenitor Cells Leads to Homing in Acute Lung Injury
Respiratory Research 2007, 8:50 doi:10.1186/1465-9921-8-50
Oct. 25. 2011, Dr. Pavel Babal
Changes of Glycosylation in Thyroid Gland Cancers - Possible New Markers and Therapy Targets
Oct. 18. 2011, David Clark
Charge Transport in DNA Duplex/Quadruplex Conjugates
Biochemistry 2003, 42, 14159-14165
Oct. 11. 2011, Meshann Fitzgerald
The Inflammasome Mediates Hyperoxia-Induced Alveolar Cell Permeability
J Immunol 2010;184;5819-5826
Oct. 04. 2011, William T. Gerthoffer, Ph.D.
Inhibition of House Dust Mite–induced Allergic Airways Disease by Antagonism of microRNA-145 is Comparable to Glucocorticoid Treatment
J Allergy Clin Immunol Vol 128, Number 1, July 2011
Sept. 20, 2011, Abdallah Alzoubi
Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure
Circulation 2009, 120:1951-1960 
Sept. 06, 2011, Dr. Masahiko Oka
Dehydroepiandrosterone and experimental PH
May 10, 2011, Cristhiaan Ochoa
Meningococcus Hijacks a β2-Adrenoceptor/ β-Arrestin Pathway to Cross Brain Microvasculature Endothelium
Cell 143, 1149-1160, December 23, 2010
May 03, 2011, Luai Hasoun
5-Methyltetrahydrofolate Inhibits Photosensitization Reactions and Strand Breaks in DNA
The FASEB Journal Vol. 21 July 2007
Apr. 26, 2011, Terrance Platt
Rho-kinase-mediated Regulation of Receptor-agonist-stimulated Smooth Muscle Contraction
Eur J Physiol (2006) 453:223-232
Apr. 19, 2011, Alicia Waggoner
Moderate Postnatal Hyperoxia Accelerates Lung Growth and Attenuates Pulmonary Hypertension in Infant Rats after Exposure to Intra-amniotic Endotoxin
AJP Lung Cell Mol Physiol 299: L735-L748, 2010
Apr. 05, 2011, Ashley DeCoux
Viable Neutrophils Release Mitochondrial DNA to form Neutrophil Extracellular Traps
Cell Death and Differentiation (2009) 16, 1438-1444
Mar. 29, 2011, Heba Khader
Methylglyoxal Scavengers Attenuate Endothelial Dysfunction Iinduced by Methylglyoxal and High Concentrations of Glucose
British Journal of Pharmacology (2010) 161 1843-1856 1843
Mar. 22, 2011, Ningyong Xu
Protein Kinase C-induced Phosphorylation of Orai1 Regulates the Intracellular Ca2+ Level via the Store-operated Ca2+ Channel
THE JBC VOL. 285, NO. 33, pp. 25720-25730, August 13, 2010
Mar. 01, 2011, Sukrutha Chettimada
Evidence of Dysfunction of Endothelial Progenitors in Pulmonary Arterial Hypertension
Am J Respir Crit Care Med Vol 180. pp 780-787, 2009
Feb. 15, 2011, Audrey Vasauskas
Calcium- and FK506-Independent Interaction Between the Immunophilin FKBP51 and Calcineurin
Journal of Cellular Biochemistry 84:460±471 (2002)
Feb. 08, 2011, Pierre Kadeba
The Hsp90-binding Peptidylprolyl Isomerase FKBP52 Potentiates Glucocorticoid Signaling in vivo
The EMBO Journal Vol. 22 No. 5 pp. 1158±1167, 2003
Feb. 01, 2011, Jyoti Rai
Tobacco Smoke Induces the Generation of Procoagulant Microvesicles From Human Monocytes/Macrophages
Arterioscler Thromb Vasc Biol 2010;30:1818-1824
Jan. 25, 2011, April Scruggs
Bioorthogonal Metabolic Glycoengineering of Human Larynx Carcinoma (HEp-2) Cells Targeting Sialic Acid
Beilstein Journal of Organic Chemistry 2010, 6, No. 24
Jan. 18, 2011, Jamie Hill
Mitochondrial DNA Nucleoids Determine Mitochondrial Genetics and Dysfunction
The International Journal of Biochemistry & Cell Biology 41 (2009) 1899-1906



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