Clayton Smith, M.D., Ph.D.

Staff Radiation Oncologist
Assistant Professor of Interdisciplinary Clinical Oncology

 

USA Mitchell Cancer Institute
1660 Springhill Avenue
Mobile, Alabama 36604
(251) 445-8362
 

Professional Profile

Primary Interests:
- Brain tumors and radiosurgery, gastrointestinal malignancies, and genitourinary malignancies including prostate and bladder cancers

Professional Experiences:
- Assistant Professor of Interdisciplinary Clinical Oncology, Division of Radiation Oncology, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, July 2016 - Present.

Education and Training:
Vanderbilt University Medical Center, Nashville, TN
Radiation Oncology Residency Program, July 2012-June 2016
Chief Resident, July 2015-June 2016

The Methodist Hospital, Houston, TX
Transitional Year Residency Program, July 2011-June 2012

Tulane University, New Orleans, LA
M.D./Ph.D., Neuroscience, May 2011 (Dissertation Title: Contributions of rat hippocampus and orbitofrontal cortex to recent and remote memory consolidation.)
B.S., Neuroscience, magna cum laude, May 2004

Certification:
- American Board of Radiology – Radiation Oncology: Board Certified May 2017

Professional Activities:
- Co-Chair, Mitchell Cancer Institute “Oncology Outlook” CME Conference Mar 31-Apr 1, 2017. Arranged speakers/topics and gave talks regarding indications and outcomes for SRS and SBRT.

Honors and Awards:
- Sept. 2016 -- ASTRO Resident Clinical/Basic Science Award in Biology  
- June 2016 -- RSNA Roentgen Resident Research Award
- July 2012 - June 2016 -- American Board of Radiology Holman Research Pathway
- July 2013 - June 2015 -- NIH Loan Repayment Program - NCI Extramural Research Contract: “Investigation of ENOX1, a novel target of angiogenesis, in the radiosensitization of glioblastoma tumor vasculature" ($70,000)
- July 2009 - June 2011 -- Medical Student Merit Scholarship
- Aug 2004 - June 2006 -- Jack Aron Scholarship (School of Medicine)
- May 2004 -- Arnold Gerall Award in Neuroscience (Undergraduate)
- May 2004 -- Senior Scholar Award in Neuroscience (Undergraduate)

Organizations and Memberships:
- Jan 2017-Present -- NRG Oncology, New Investigators Committee member
- July 2012-Present -- American Society for Radiation Oncology (ASTRO)
- July 2012-Present -- American Society of Clinical Oncology (ASCO)
- July 2014-June 2016 -- Vanderbilt House Staff Advisory Council      

 

Publications:

Smith, C.A., Mont, S., Traver, G., Sekhar, K.R., Crooks, P.A., & Freeman, M.L. (2016). Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy. Oncotarget. Oct 24. doi: 10.18632/oncotarget.12845.

Kathirvelu, B., East, B.S., Hill, A.R., Smith, C.A., & Colombo, P.J. (2013). Lentivirus-mediated chronic expression of dominant-negative CREB in the dorsal hippocampus impairs memory for place learning and contextual fear conditioning. Neurobiology of Learning and Memory, 99, 10-16.

Smith, C.A., East, B.S., & Colombo, P.J. (2010). The orbitofrontal cortex is not necessary for acquisition or remote recall of socially transmitted food preferences. Behavioural Brain Research, 208, 243-249.

Brightwell, J.J., Smith, C.A., Neve, R.L., & Colombo, P.J. (2008). Transfection of mutant CREB in the striatum, but not the hippocampus, impairs long-term memory for response learning. Neurobiology of Learning and Memory, 89, 27-35.

Smith, C.A., Countryman, R.A., Sahuque, L.L., & Colombo, P.J. (2007). Time-courses of fos expression in rat hippocampus and neocortex following acquisition and recall of a socially transmitted food preference. Neurobiology of Learning and Memory, 88, 65-74.

Brightwell, J.J., Smith, C.A., Neve, R.L., & Colombo, P.J. (2007). Long-term memory for place learning is facilitated by expression of cAMP response-element binding protein in the dorsal hippocampus. Learning & Memory, 14, 195-199.

Brightwell, J.J., Smith, C.A., Countryman, R.A., Neve, R.L., & Colombo, P.J. (2005). Hippocampal overexpression of mutant CREB blocks long-term, but not short-term, memory for a socially transmitted food preference. Learning & Memory, 12, 12-17.

 

Editorials and Reviews:

Smith, C.A. and Kachnic, L.A. (2017). Evolving Role of Radiotherapy in the Management of Rectal Carcinoma. Surgical Oncology Clinics of North America, 26, 455-466.

Smith, C.A. and Freeman, M.L. (2016). Preclinical Advances in Combined Modality Cancer Immunotherapy with Radiation Therapy. International Journal of Radiation Oncology, Biology, Physics, 94, 11-14.

Smith, C.A. and Freeman, M.L. (2014). Oncology Scan – Autophagy and the Radiation Response. International Journal of Radiation Oncology, Biology, Physics, 90, 7-10.

 

Presentations and Abstracts:

Smith, C.A., Sekhar, K. R., Crooks, P.A., Traver, G., & Freeman, M.L. (2016). Targeting ENOX1 Impairs Repair of DNA DSBs in Endothelial Cells and Increases Survival in Tumor-Bearing Mice. American Society for Radiation Oncology Oral Poster Presentation

Smith, C.A., McTyre, E., Isom, S., Kennedy, V., Luo, G., Morales-Paliza, M., Hinson, W., Cmelak, A.J., Tatter, S., Chan, M., & Attia, A. (2015). A Multi-institutional Analysis of Patients Treated With Stereotactic Radiosurgery for Brain Metastases From Radioresistant Histologies. American Society for Radiation Oncology Poster Presentation. 

Smith, C.A., Sekhar, K.R., Benamar, M., Venkateswaran, A., Sasi, S., Penthala, N.R., Crooks, P.A., Hann, S.R., Geng, L., Abbas, T., & Freeman, M.L. (2014). NPM1 as a Target for Radiosensitization of NSCLC Using a Genetic Model and Inhibitor YTR107. American Society for Radiation Oncology Oral Poster Presentation

Zatarain, L.A., Smith, C.A., Dietrich, M.S., Niermann, K.J., Ridner, S.H., & Murphy, B.A. (2014). A longitudinal study of body composition in head and neck cancer patients undergoing radiation-based therapy utilizing DEXA and CT imaging. Multinational Association of Supportive Care in Cancer Abstract.

Zatarain, L.A., Smith, C.A., Dietrich, M.S., Niermann, K.J., Gilbert, J., Hadziahmetovic, M., Ridner, S.H., & Murphy, B.A. (2014). A feasibility study of dynasplint to prevent trismus in head and neck cancer patients receiving radiation therapy. American Society of Clinical Oncology Abstract.

Kathirvelu, B., East, B.S., Hill, A.R., Smith, C.A., & Colombo, P.J. (2010). Lentivirus overexpression of mutant CREB in the dorsal hippocampus impairs long-term memory retention of place learning and contextual fear conditioning. Society for Neuroscience Abstract.

Smith, C.A., O’Malley, J.N., & Colombo, P.J. (2008). Decreased expression of Zif268 in rat hippocampus following remote recall and relationships between Zif268 expression and CREB phosphorylation in hippocampus and orbitofrontal cortex following acquisition and recall. Society for Neuroscience Abstract.

Smith, C.A., Neeland, M.A., & Colombo, P.J. (2007). cAMP response element-binding protein phosphorylation is increased in the orbitofrontal cortex of rats following remote recall of a socially transmitted food preference. Society for Neuroscience Abstract.

Kathirvelu, B., Smith, C.A., & Colombo, P.J. (2007). Socially transmitted food preference (STFP) learning-associated changes in the levels of phosphorylated T286 Calcium/ Calmodulin-dependent protein kinase-II (pT286 CaM KII) in the hippocampal formation. Society for Neuroscience Abstract.

Brightwell, J.J., Smith, C.A., Neve, R.L., & Colombo, P.J. (2004). Blockade of CREB function in the dorsolateral striatum impairs long-term memory for response learning. Society for Neuroscience Abstract.

Countryman, R.A., Sahuque, L.L., Smith, C.A., Shukla, S.J., & Colombo, P.J. (2003). c-fos is expressed differentially in cortical brain regions of rats during acquisition and recall of a socially transmitted food preference. Society for Neuroscience Abstract.

 

Email Newsletters

Connect With Us