|Principal Investigator/ Physician||William Taylor, MD|
|Sponsor||Alliance for Clinical Trials in Oncology|
|Contact Email||MCI Clinical Trials|
Protocol: Preoperative Extended Chemotherapy vs. Chemotherapy Plus Hypofractionated Radiation Therapy For Borderline Resectable Adenocarcinoma Of The Head Of The Pancreas
Inclusion Criteria: Cytologic or histologic proof of adenocarcinoma of the pancreatic head or uncinate process; TNM Stage: TX, T1-4N0-1orNxM0; Must meet any one or more of the following on CT/MRI: 1) An interface is present between the primary tumor and the superior mesenteric vein or portal vein and measures ≥ 180° of the circumference of the vessel wall, 2) Short-segment occlusion of the SMV-PV is present with normal vein above and below the level of obstruction that is amenable to resection and venous reconstruction, 3) Short segment interface (of any degree) is present between tumor and hepatic artery with normal artery proximal and distal to the interface that is amenable to resection and reconstruction, 4) An interface is present between the tumor and superior mesenteric artery or celiac axis measuring < 180° of the circumference of the vessel wall.
Exclusion Criteria: Patients with less extensive disease than the above four (4) criteria; Patients with more extensive disease than the above 4 criteria; Any interface between the tumor and the aorta.
Clinical Trials.Gov Link:https://clinicaltrials.gov/ct2/show/NCT02839343?term=A021501&recrs=a&rank=1
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