Erin Eun-Young Ahn, Ph.D.

Associate Professor of Oncologic Sciences

 

2016-02-26 MCI Erin Ahn resized1.jpg

 

USA Mitchell Cancer Institute
1660 Springhill Avenue
Mobile, Alabama 36604
(251) 445-9805
eahn@health.southalabama.edu

Professional Profile

Primary Interests:
- SON-mediated constitutive/alternative RNA splicing and cancer
- Roles of non-coding RNAs in cancer development and progression
- Regulation of transcription and RNA splicing in cancer stem cells
- Identification of novel targets for cancer therapy

Education:
- B.S., Biology Education, Seoul National University, South Korea (1996)
- M.S., Cell and Molecular Biology, Seoul National University, South Korea (1998)
- Ph.D., Molecular and Cellular Pathology, University of Alabama at Birmingham (2003)
- Postdoctoral Fellowships: The Scripps Research Institute (2004-2008), Moores Cancer Center, University of California San Diego (2008-2009)

Professional Appointments:
- Associate Professor of Oncologic Sciences, USA Mitchell Cancer Institute (2016-present)
- Assistant Professor of Oncologic Sciences, USA Mitchell Cancer Institute (2012-2016)
- Adjunct Assistant Professor, Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama (May 2013-present)
- Assistant Project Scientist, Moores Cancer Center, University of California San Diego (2009-2012)

Professional Honors / Awards: 
- Invited Speaker, Workshop on Myeloid development, American Society of Hematology Annual meeting, Orlando, FL (2015)
- Invited Speaker, Workshop on Myeloid development, American Society of Hematology Annual meeting, New Orleans, LA (2013)
- Invited Speaker, Seminar Series at HudsonAlpha Institute for Biotechnology, Huntsville, AL (2012)
- Travel Award for postdoctoral fellow. 50th annual Meeting, American Society of Hematology (2008)
- International Awards for Research in Leukemia and Allied Conditions, Lady TATA Memorial Trust, United Kingdom (2005-2007)
- Best Poster Award. Moores UCSD Cancer Center Annual Retreat (2007)
- The John R. Durant Award for the Excellence in Cancer Research.  First Place in Graduate Student Category. Comprehensive Cancer Center, University of Alabama at Birmingham (2001)
- College Dean Award (1st honor) for the excellence in undergraduate study. Seoul National University, Seoul, Korea (1996) 

Selected Publications:

  1. Kim JH,  Baddoo MC, Park EY, Stone JK, Park H, Butler TW, Huang G, Yan X, Pauli-Behn F, Myers RM, Tan M, Flemington EK, Lim ST, Ahn EY.   SON and its alternatively spliced isoforms control MLL complex-mediated H3K4me3 and transcription of leukemia-associated genes. Molecular Cell (2016) 61:859-873
  2. Schmitt DC, Madeira da Silva L, Zhang W, Liu Z, Arora R, Lim S, Schuler AM, McClellan S, Andrews JF, Kahn AG, Zhou M, Ahn EY, Tan M. ErbB2-intronic microRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling. Cell Death Dis. (2015) 2015 May; 6(5): e1742.
  3. Kim JH, Ahn EY. Transcript variants of RUNX1T1: new insight into t(8;21)-positive leukemia. Leuk Res  (2014) 38(9):1018-1019.
  4. Hickey CJ, Kim JH, Ahn EY.   New discoveries of old SON: A link between RNA splicing and cancer. J. Cell. Biochem. (2014) 115(2):224-231
  5. DeKelver RC, Yan M, Ahn EY, Speck NA, Zhang DE. Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.  Blood (2013) 121(18):3714-3717
  6. Desai S,  Liu Z, Yao J, Patel N, Chen J, Wu Y, Ahn E, Fodstad O, Tan M. Heat Shock Factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of Autophagy -related Protein 7 (ATG7). J Biol Chem  (2013) 288(13):9165-9176
  7. Ahn E, Higashi T, Yan M, Matsuura S, Hickey CJ, Lo MC, Shia WJ, DeKelver RC, Zhang DE.  SON regulates GATA-2 through transcriptional control of the miR-23a~27a~24-2 cluster. J Biol Chem  (2013) 288(8):5381-5388
  8. Lo MC, Peterson LF,  Yan M, Cong X, Jin F, Shia WJ, Matsuura S, Ahn, EY, Komeno Y, Ly M, Ommen HB, Hokland P, Willman CL, Ren B, Zhang, DE.  Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.  Blood  (2012) 120(7):1473-1484
  9. Matsuura S., Yan, M., Lo M.C., Ahn EY, Weng S., Dangoor D., Matin M., Higashi T., Feng G.S., and Zhang D.E.  Negative Effects of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Signaling in a Murine Model of t(8;21)-Induced Leukemia. Blood (2012) 119(13): 3155-3163
  10. Ahn EY, DeKelver RC, Lo MC, Nguyen TA, Matsuura S., Boyapati A., Pandit S., Fu X.D., and Zhang, D.E.   SON controls cell cycle progression by coordinated regulation of RNA splicing. Molecular Cell (2011) 42: 185-198
  11. Pawar P., Ma L., Byon C.H., Liu H., Ahn EY, Jhala N., Arnoletti J.P., McDonald J.M. ,and Chen Y.   Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: Role of calmodulin. Clin Cancer Res (2009) 15(4):1288-1296
  12. Ahn EY, Yan M., Malakhova O.A., Lo M.C., Boyapati A., Ommen H.B., Hines R., Hokland P., and Zhang D.E.   Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis.  Proc Natl Acad Sci U S A (2008) 105(44): 17103-17108. 
  13. Yan M., Ahn EY, Hiebert S., Zhang D.E.  RUNX1/AML1 DNA binding domain and ETO/MTG8 NHR2 oligomerization domain are critical to AML1-ETO9a induced leukemogenesis.  Blood (2008) 113: 883-886
  14. Dayyani F., Wang J., Yeh JR, Ahn EY, Tobey E., Zhang Y., Zaidi S.T., Zhang D.E., Bernstein, I.D., Peterson, R.T., and Sweetser, D.A.  Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperate with AML1-ETO to affect myeloid cell proliferation and survival. Blood  (2008) 111 (8); 4338-4347.
  15. Peterson LF, Boyapati A., Ahn EY, Biggs JR., Okumura A., Lo M.C., Yan M., and Zhang D.E.   Acute Myeloid Leukemia with the 8q22;21q22 Translocation: Secondary Mutational Events and Alternative t(8;21) Transcript.  Blood (2007) 110: 799-805.
  16. Pan G., Ahn EY, Chen Y., Feng G., Reddy V., Jhala N.C., and McDonald J.M. (2007) Reciprocal co-expression of Fas and Fas ligand in human cholangiocarcinoma.  Int J. Oncol (2007) 31(4):843-50.
  17. Wu X., Ahn EY, McKenna M.A., Yeo H, and McDonald J.M.  Fas binding to calmodulin regulars apoptosis in osteoclasts.  J Biol Chem (2005) 280: 29964-29970
  18. Ahn EY, Lim ST, Cook WJ, and McDonald JM. Calmodulin binding to the Fas death domain:  Regulation by Fas activation.  J Biol chem (2004) 279: 5661-5666
  19. Ahn EY, Pan,G, Oh, JH, Tytler EM, and McDonald JM.  The combination of calmodulin antagonists and interferon-gamma induces apoptosis through caspase-dependent and –independent pathways in cholangiocarcinoma cells.  Am J. Pathol (2003) 163: 2053-2063
  20. Ahn EY, Pan G, Vickers SM, and McDonald JM.  Interferon-gamma upregulates apoptosis-related moluecules and enhances Fas-mediated apoptosis in human cholangiocarcinoma.  Int J. Cancer (2002) 100: 445-451
  21. Vickers SM, Ahn EY, Jhala NC, Pan G, Bland KI, and McDonald JM. (2002) Tamoxifen/Fas-induced growth inhibition of human cholangiocarcinoma by gamma-interferon.  Ann Surg (2002)  235: 872-878
  1. Lee JE, Ahn, EY, Ahn TI.  Development of a plasmid vector for overproduction of beta-galactosidase in E. coli by using genetic components of groEx from symbiotic bacteria in Amoeba proteus.  Microbiol  Biotechnol  (1998) 8: 509-516  

Email Newsletters

Connect With Us