Professor and Vice Chair, Department of Cell Biology and Neuroscience
Associate Dean for Medical Education.
Postdoctoral Studies: University of South Alabama
Ph.D. - University of South Alabama
Dr. Susan LeDoux is currently Professor and Vice-Chair in the Department of Cell Biology and Neuroscience and Associate Dean for Medical Education in the College of Medicine at the University of South Alabama. As a trained anatomist, Dr. LeDoux's primary teaching responsibility is in Medical Gross Anatomy. However, she also teaches in Medical Histology and Cell Biology, and in an Interdisciplinary Graduate Course. Her research interests are focused on the role of mitochondrial DNA damage and repair in cellular responses to genotoxic injury. In collaboration with Dr. Glenn Wilson, Dr. LeDoux's laboratory was the first to discover that base excision DNA repair occurs within mitochondria. Over the past fifteen years much of Dr. LeDoux's work has been directed toward the study of mitochondrial DNA repair in the central nervous system (CNS). The discovery of a correlation between decreased mitochondrial DNA repair capacity and increased sensitivity to genotoxic insults among different populations of CNS cells led to the development of strategies to protect cells by enhancing mitochondrial DNA repair. Using gene therapy approaches, our laboratory has made the exciting observation that altering mitochondrial DNA repair capacity by targeting of specific DNA repair proteins to mitochondria, prior to the initiation of genotoxic stress, causes enhanced cellular viability. This finding has provided the necessary groundwork for future translational studies to treat a variety of neurodegenerative diseases.
LeDoux S.P., Druzhyna N.M., Hollensworth S.B., Harrison J.F., and Wilson G.L.. Mitochondrial DNA repair: a critical player in the response of cells of the CNS to genotoxic insults. Neuroscience 145(4):1249-59, 2007.
Harrison J.F., Hollensworth S.B., Spitz D.R., Copeland W.C., Wilson G.L., LeDoux S.P. Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance. Nucleic Acids Res 22(14):4660-4671, 2005.
Grishko V.I., Rachek L.I., Spitz D.R., Wilson G.L., and LeDoux S.P. Contribution of mitochondrial DNA repair to cell resistance from oxidative stress. J Biol Chem. 280(10):8901-5, 2005.
Druzhyna, N.M., Hollensworth S.B., Kelley M.R.,Wilson G.L. and LeDoux, S.P. Targeting Human 8-Oxoguanine Glycosylase to Mitochondria of Oligodendrocytes Protects Against Menadione-Induced Oxidative Stress. Glia 42:370-378, 2003.
Dobson, A. W., Kelley M. R.,Wilson, G.L., and LeDoux, S.P. Targeting DNA Repair Proteins to Mitochondria. In: Mitochondrial DNA; Methods and Protocols. (Ed. W.C. Copeland) Humans Press, pp.351-362 (2002).
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