Associate  Professor
Phone: (251) 414-8179
FAX: (251) 460-7931
pbrett@southalabama.edu

Burkholderia pseudomallei and Burkholderia mallei Host-Pathogen Interactions

Dr. Brett received his Ph.D. in Bacterial Pathogenesis from the University of Calgary, Calgary, Alberta in 1998 and conducted his postdoctoral training at University College London, London, United Kingdom and Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana. Dr. Brett joined the Department of Microbiology and Immunology at the University of South Alabama College of Medicine in November 2008 and currently serves as an ad hoc peer reviewer for a number of journals including Antimicrobial Agents and Chemotherapy, Infection and Immunity, Journal of Bacteriology, Molecular Microbiology, and PLos Pathogens.

Research in Dr. Brett's lab is focused on elucidating the molecular mechanisms used by Burkholderia pseudomallei (melioidosis) and Burkholderia mallei (glanders) to subvert host innate immune defenses. In particular, his lab is interested in determining how the virulence-associated type III secretion systems (T3SS) and type VI secretion systems (T6SS) expressed by these organisms influence the outcomes of interactions with human and murine macrophages. In addition, studies are ongoing in his lab to investigate the protective capacities of novel meliodosis and glanders polysaccharide-based vaccine candidates.

 

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Recent Publications

Click here for a list of recent publications.

 

 

Related Links

 

Glanders and melioidosis information:

http://www.cdc.gov/nczved/divisions/dfbmd/diseases/glanders/

http://www.cdc.gov/nczved/divisions/dfbmd/diseases/melioidosis/

 

Burkholderia genome information:

http://www.burkholderia.com/

http://www.sanger.ac.uk/resources/downloads/bacteria/burkholderia-pseudomallei.html

http://gsc.jcvi.org/projects/msc/burkholderia_mallei/

http://pathema.jcvi.org/cgi-bin/Burkholderia/PathemaHomePage.cgi

https://www.patricbrc.org/

 

Microbiology:

http://www.asm.org/

http://www.csm-scm.org/

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