|Name||Jonathan G. Scammell, Ph.D.|
|Ph.D.||University of Florida, Gainesville, FL|
|Post-doctoral||Yale University, New Haven, CT|
|Current Position||Chair, Department of Comparative Medicine
Professor of Comparative Medicine and Pharmacology
Our interest in the large and quite homologous molecular immunophilins FKBP51 and FKBP52 began over a decade ago when we were studying steroid resistance in New World primates and discovered that these proteins play a role. It has since been discovered that these proteins are important in regulating cortisol responsiveness in asthma, cancer and even post-traumatic stress disorder in humans. Thus, understanding different physiological and biochemical traits in another species led to insight into basic biological mechanisms relevant to human disease.
Our work now is a collaboration with my colleague, Dr. Donna Cioffi, in the Department of Biochemistry and Molecular Biology. We are studying the mechanisms by which FKBP51 and FKBP52 regulate store-operated calcium entry in pulmonary endothelial cells. This represents a novel way that permeability across the endothelial barrier may be modified and may lead to new targets for treatment of acute lung injury. Like our work on steroid resistance in the squirrel monkey, we have found that FKBP51 and FKBP52 have opposite effects on lung permeability, which leads us to the conclusion that the way that these proteins interact with their targets must be different. We are interested in knowing how.
1. Denny WB, Valentine DL, Reynolds PD, Smith DF, Scammell JG. Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding. Endocrinology 141:4107-4113 (2000).
2. Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J. Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Proc Natl Acad Sci USA 100:868-873 (2003).
3. Hubler TR, Scammell JG. Intronic hormone-response elements mediate regulation of FKBP5 by progestins and glucocorticoids. Cell Stress Chaperones 9:243-252 (2004).
4. Denny WB, Prapapanich V, Smith DF, Scammell JG. Structure-function analysis of squirrel monkey FKBP51, a potent inhibitor of glucocorticoid receptor activity. Endocrinology 146:3194-3201 (2005).
5. Sadosky PW, Scammell JG. Increased production of 11β-hydroxysteroid dehydrogenase type 2 in the kidney microsomes of squirrel monkeys (Saimiri spp.). Comparative Medicine 58:180-187 (2008).
6. Gross KL, Westberry JM, Hubler TR, Sadosky PW, Singh RJ, Taylor RL, Scammell JG. Androgen resistance in squirrel monkeys (Saimiri spp.). Comparative Medicine 58:381-388 (2008).
7. Vasauskas AA, Hubler TR, Mahanic C, Gibson SV, Kahn AG, Scammell JG. Regulation and distribution of squirrel monkey chorionic gonadotropin and secretogranin II in the pituitary. Gen Comp Endocrinol 170: 509-513 (2011).
8. Vasauskas AA, Hubler TR, Boston L, Scammell JG. Tissue-specific expression of squirrel monkey chorionic gonadotropin. Gen Comp Endocrinol 170: 514-521 (2011).
9. Cioffi DL, Hubler TR, Scammell JG. Organization and function of the FKBP52 and FKBP51 genes. Curr Opin Pharmacol 11:308-313 (2011).
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