Ivan F. McMurtry, Ph.D.

 

Ph.D.   Colorado State University
Post-doctoral   Cardiopulmonary Research
University of Colorado
Current Position   Professor
Phone   (251) 414-8038 
E-mail   ifmcmurtry@southalabama.edu

 

Research Interests

The primary focus of my laboratory's research is the regulation of pulmonary vascular tone and structure and the pathogenesis of pulmonary arterial hypertension, with an emphasis on the interactive roles of vasoactive factors such as nitric oxide, endothelin-1, thromboxane, serotonin, and sphingosine-1-phosphate. Various experimental preparations, including catheterized rats and mice, perfused rat and mouse lungs, isolated pulmonary artery rings, and cultured vascular smooth muscle and endothelial cells, are used in physiological, pharmacological, and molecular biological experiments to investigate mechanisms of control of vascular tone and structure in both normotensive and hypertensive lungs. Current focus is on the role of Rho GTPases, such as RhoA and Rac1, and their downstream effectors in mediating the cellular effects of vasoactive factors. Students and trainees play a direct role in this research by assuming primary responsibility for the design, performance, analysis, presentation, and publication of projects related to the overall goals.

Representative Publications

  1. McMurtry IF. Erythropoieses in the white rat. M.S. Thesis, University of Nebraska, 1968.
  2. Will DH, Frith CH, McMurtry IF, MacCarter, DJ. Effects of hypertension and hypoxemia on arterial metabolism and structure. In: Comparative Pathophysiology of Circulatory Disturbances. ed., CM Bloor, New York, Plenum, 1972, p185-302.
  3. McMurtry IF, Frith CH, Will DH. Cardiopulmonary responses of male and female swine to simulated high altitude. J Appl Physiol 35:459-462, 1973.
  4. McMurtry IF. Hypoxia and arterial metabolism in swine. Ph.D. Thesis, Colorado State University, 1973.
  5. Frith DH, McMurtry IF, Alexander AF, Will DH. Influence of hypertension and hypoxemia on arterial biochemistry and morphology in swine. Atherosclerosis 20: 189-206, 1974.
  6. Tucker A, McMurtry IF, Reeves JT, Alexander AF, Will DH, Grover RF. Lung vascular smooth muscle as a determinant of pulmonary hypertension at high altitude. Amer J Physiol 228:762-767, 1975.
  7. Grover RF, Will DH, Reeves JT, Weir EK, McMurtry IF, Alexander AF. Genetic transmission of susceptibility to hypoxic pulmonary hypertension. Prog Resp Res 9:112-117, 1975.
  8. Weir EK, McMurtry IF, Grover RF. Experimental models of complete heart block. Basic Res Cardiol 70:446-455, 1975.
  9. McMurtry IF, Reeves JT, Will DH, Grover RF. Hemodynamic and ventilatory effects of skin-cooling in cattle. Experientia 31:1303-1304, 1975.
  10. McMurtry IF, Davidson AB, Reeves JT, Grover RF. Inhibition of hypoxic pulmonary vascoconstriction by calcium antagonists in isolated rat lungs. Circ Res 38:99-104, 1976.
  11. Tucker A, McMurtry IF, Reeves JT, Grover RF. Attenuation of hypoxic pulmonary vasoconstriction by verapamil in intact dogs. Proc Soc Exp Biol Med 151:611-626, 1976.
  12. McMurtry IF, Weir EK, Reeves JT, Will DH, Grover RF. Prostaglandin synthesis does not mediate the pulmonary vasodilatory effect of acetylcholine in hypoxic cattle. Prostaglandins 11: 63-69, 1976.
  13. Weir EK, McMurtry IF, Tucker A, Reeves JT, Grover RF. Prostaglandin synthetase inhibitors do not decrease hypoxic pulmonary vasoconstriction. J Appl Physiol 41:714-718, 1976.
  14. McMurtry, IF, Tucker A, Reeves JT, Grover RF. Hyperreactivity of normotensive and hypertensive pulmonary vasculature in spontaneously hypertensive rats. In: Spontaneous Hypertension: Its Pathogenesis and Complications. Proc 2nd Int Symp on the Spontaneously Hypertensive Rat. April 1976, DHEW Publication NO. 77:1179.
  15. Tucker A, McMurtry IF, Alexander AF, Reeves JT, Grover RF. Lung mast cell density and distribution in chronically hypoxic animals. J Appl Physiol 42:174-178, 1977.
  16. McMurtry IF, Hookway BW, Roos SD. Red blood cells play a crucial role in maintaining vascular reactivity to hypoxia in isolated rat lungs. Chest 71s: 255s-256s, 1977.
  17. McMurtry IF, Dickey DW, Souhrada JF, Reeves JT, Grover RF. Vascular effects of compound 48/80 in isolated lungs and pulmonary arteries. Artery 3:1-12, 1977.
  18. McMurtry IF, Reeves JT, Will DH, Grover RF. Reduction of bovine pulmonary hypertension by normoxia, verapamil and hexoprenaline. Experientia 33:1192-1194, 1977.
  19. McMurtry IF, Hookway BW, Roos SD. Red blood cells but not platelets prolong vascular reactivity of isolated rat lungs. Am J Physiol 234:H186-H191, 1978.
  20. Davidson A, McMurtry IF, Reeves JT. Pulmonary vascular effects of verapamil. Am Heart J 95:810-811, 1978.
  21. McMurtry IF, Petrun MD, Reeves JT. Lungs from chronically hypoxic rats have decreased pressor response to acute hypoxia. Am J Physiol 235:H104-H109, 1978.
  22. Will DH, McMurtry IF, Reeves JT, Grover RF. Cold-induced pulmonary hypertension in cattle. J Appl Physiol 45: 469-473, 1978.
  23. Moore LG, McMurtry IF, Reeves JT. Effects of sex hormones on cardiovascular and hematologic responses to chronic hypoxia in rats. Proc Soc Exp Biol Med 158:658-662, 1978.
  24. Grover RF, Hyers TM, McMurtry IF, Reeves JT. High altitude pulmonary edema. In: Pulmonary Edema, ed., A.P. Fishman and E.M. Renkin, Bethesda, American Physiological Society, 1979, p229-240.
  25. McMurtry IF, Petrun MD, Tucker A, Reeves JT. Pulmonary vascular reactivity in the spontaneously hypertensive rat. Blood Vessels 16:61-70, 1979.
  26. Weir EK, Will DH, Alexander AF, McMurtry IF, Looga R, Reeves JT, Grover RF. Vascular hypertrophy in cattle susceptible to hypoxic pulmonary hypertension. J Appl Physiol 46:517-521, 1979.
  27. Reeves JT, Wagner WW, McMurtry IF, Grover RF. Physiological effects of high altitude on the pulmonary circulation. Int Rev Physiol III 20:289-310, 1979.
  28. Voelkel NF, Gerber JG, McMurtry IF, Reeves JT, Nies AS. Release of dilator prostaglandins from lung tissue during angiotensin II-induced vasoconstriction. Adv Prostaglandin Thromboxane Res 7:957-960, 1979.
  29. Voelkel NF, McMurtry IF, Reeves JT. Chronic propranolol treatment blunts right ventricular hypertrophy in rats at high altitude. J Appl Physiol 48: 473-478, 1980.
  30. McMurtry IF, Morris, Petrun MD. Blunted hypoxic vasoconstriction in lungs from short-term high-altitude rats. Am J Physiol 238:H849-H857, 1980.
  31. Voelkel NF, Morris KG, McMurtry IF, Reeves JT. Calcium augments hypoxic vasoconstriction in lungs from high-altitude rats. J Appl Physiol 49:450-455, 1980.
  32. Gerber JG, Voelkel NF, Nies AS, McMurtry IF, Reeves JT. Moderation of hypoxic vasoconstriction by infused arachidonic acid: role of PGI2. J Appl Physiol 49:107-112, 1980.
  33. Rounds SIS, Moore LG, Voelkel NF, McMurtry IF, Reeves JT. Cardiac output is decreased and hypoxic vasoconstriction is intact in chronically hypoxic sheep. Proc Soc Exp Biol Med 165:1-5, 1980.
  34. Voelkel NF, McMurtry IF, Reeves JT. Hypoxia impairs vasodilation in the lung. J Clin Invest 67:238-246, 1981.
  35. Rounds S, McMurtry IF. Inhibitors of oxidative ATP production cause transient vasoconstriction and block subsequent pressor responses in rat lungs. Circ Res 48:393-400, 1981.
  36. Voelkel NF, Gerber JG, McMurtry IF, Nies AS, Reeves JT. Release of vasodilatory prostaglandin, PGI2, from isolated rat lung during vasoconstriction. Circ Res 48:207-213, 1981.
  37. Voelkel NF, Hegstrand L, Reeves JT, McMurtry IF, Molinoff PB. Effects of hypoxia on density of beta-adrenergic receptors. J Appl Physiol 50:363-366, 1981.
  38. Rounds SS, McMurtry IF, Reeves JT. Glucose metabolism accelerates the decline of hypoxic vasoconstriction in rat lungs. Resp Physiol 44:239-249, 1981.
  39. Newman JH, McMurtry IF, Reeves JT. Blunted pulmonary pressor responses to hypoxia in blood-perfused, ventilated lung isolated from oxygen toxic rats: possible role of prostaglandins. Prostaglandins 22:11-20, 1981.
  40. Walker BR, Voelkel NF, McMurtry IF, Adams M. Evidence for the diminished sensitivity of the hamster pulmonary vasculature to hypoxia. J Appl Physiol 52:1571-1574, 1982.
  41. McMurtry IF, Stanbrook HS, Rounds S. The mechanism of hypoxic pulmonary vasoconstriction - a working hypothesis. In: Oxygen Transport to Human Tissues, ed., JA Loeppky and ML Riedesel, New York, Elsevier, 1982, p77-89.
  42. McMurtry IF, Rounds S, Stanbrook HS. Studies of the mechanism of hypoxic pulmonary vasoconstriction. Adv Shock Res 8:21-33, 1982.
  43. Shasby DM, VanBenthuysen KM, Tate RM, Shasby SS, McMurtry IF, Repine JE. Granulocytes mediate acute edematous lung injury in rabbits and isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals. Am Rev Resp Dis 125:443-447, 1982.
  44. Tate RM, Shasby DM, VanBenthuysen KM, McMurtry IF, Repine JE. Oxygen radical-induced pulmonary edema, a mechanism for the production of noncardiogenic pulmonary edema by neutrophils. Chest 81s: 575-595, 1982.
  45. VanBenthuysen KM, Shasby DM, Tate RM, Repine JE, McMurtry IF. Inhibitors of arachidonic acid metabolism prevent neutrophil-dependent acute lung injury in isolated, perfused rabbit lungs. Chest 81s: 60s-61s, 1982.
  46. Sugita T, Hyers TM, Dauber IM, Wagner WW, McMurtry IF, Reeves JT. Lung vessel leak precedes right ventricular hypertrophy in monocrotaline treated rats. J Appl Physiol 54:371-374, 1983.
  47. Tate RM, VanBenthuysen KM, Shasby DM, McMurtry IF, Repine JE. Oxygen radical mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs. Am Rev Resp Dis 126:802-806, 1982.
  48. Heffner JE, Shoemaker SA, Canham EM, Patel M, McMurtry IF, Morris HG, Repine JE. Acetyl glyceryl ether phosphorylcholine-stimulated human platelets cause pulmonary hypertension and edema in isolated rabbit lungs. J Clin Invest 71:351-357, 1983.
  49. Canham EM, Shoemaker SA, Tate RM, Harado RN, McMurtry IF, Repine JE. Mepacrine but not methylprednisolone decreases acute edematous lung injury after injection of phorbol myristate acetate in rabbits. Am Rev Resp Dis 127: 594-598, 1983.
  50. Stanbrook HS, McMurtry IF. Inhibition of glycolysis potentiates hypoxic vasoconstriction in rat lungs. J Appl Physiol 55:1467-1473, 1983.
  51. Grover RF, Wagner WW Jr, McMurtry IF, Reeves JT. Pulmonary circulation. In: Handbook of Physiology, Sec 2, The Cardiovascular System, Vol III, Peripheral Circulation and Organ Blood Flow, Part 1, ed., JT Shepherd, FM Abboud, SR Geiger. Bethesda, Am Physiological Soc 1983.
  52. McMurtry IF. Angiotensin is not required for hypoxic constriction in salt solution-perfused rat lungs. J Appl Physiol 56:375-380, 1984.
  53. Shoemaker SA, Heffner JE, Canham EM, Tate RM, Morris HG, McMurtry IF, Repine JE. Staphylococcus aureus and human platelets cause pulmonary hypertension and thromboxane generation in isolated saline-perfused rabbit lungs. Am Rev Resp Dis 129: 92-95, 1984.
  54. Burghuber O, Mathias MM, McMurtry IF, Reeves JT, Voelkel NF. Lung edema due to hydrogen peroxide is independent of cyclooxygenase products. J Appl Physiol 56: 900-905, 1984.
  55. Stanbrook HS, Morris KG, McMurtry IF. Prevention and reversal of hypoxic pulmonary hypertension by calcium antagonists. Am Rev Resp Dis 130:81-85, 1984.
  56. Redding GJ, McMurtry IF, Reeves JT. Effects of meclofenamate on pulmonary vascular resistance correlated with postnatal age in young piglets. Pediatr Res 18:579-583, 1984.
  57. Herget J, McMurtry IF. Effects of ouabain, low K+, and aldosterone on hypoxic pressor reactivity of rat lungs. Am J Physiol 248:H55-H60, 1985.
  58. McMurtry IF. BAY K 8644 potentiates and A23187 inhibit hypoxic vasoconstriction in rat lungs. Am J Physiol 249:H741-H746, 1985.
  59. Weir EK, McMurtry IF, Reeves JT. The pulmonary circulation conferences. Chest 885:199s-200s, 1985.
  60. Reeves JT, Grover RF, McMurtry IF, Weir EK. Pulmonary vascular reactivity. Bull Eur Physiopathol Respir 21:583-590, 1985.
  61. Herget J, McMurtry IF. Possible mechanisms of hypoxic pulmonary vasoconstriction. Progr Resp Res 20:5-10, 1985.
  62. McMurtry IF. Humoral control. In: Abnormal Pulmonary Circulation, ed., EH Bergofsky. New York, Churchill Livingstone, 1986, p83-126.
  63. Gillespie MN, Owasoyo JO, McMurtry IF, O'Brien RF. Sustained coronary vasoconstriction provoked by a peptidergic substance released from endothelial cells in culture. J Pharmacol Exp Ther 236:339-343, 1986.
  64. Feddersen CO, McMurtry IF, Henson P, Voelkel NF. Acetylcholine-induced pulmonary vasodilation in lung vascular injury. Am Rev Respir Dis 133:197-204, 1986.
  65. Feddersen CO, Mathias MM, McMurtry IF, Voelkel NF. Acetylcholine induces vasodilation and prostaglandin synthesis in rat lungs. Prostaglandins 31:973-987, 1986.
  66. McMurtry IF, Morris KG. Platelet-activating factor causes pulmonary vasodilation in the rat. Am Rev Respir Dis 134:757-762, 1986.
  67. Harrsion GL, McMurtry IF, Moore LG. Meclofenamate potentiates vasoreactivity to alpha-adrenergic stimulation in chronically hypoxic guinea pigs. Am J Physiol 251:H496-H501, 1986.
  68. Jackson JH, White CW, McMurtry IF, Berger EM, Repine JE. Dimethylthiourea decreases acute lung edema in phorbol myristate acetate-treated rabbits. J Appl Physiol 61:353-360, 1986.
  69. Voelkel NF, Chang SW, Worthen SG, McMurtry IF, Henson PM. PAF antagonists: different effects on platelets, neutrophils, guinea pig ileum and PAF-induced vasodilation in isolated rat lung. Prostaglandins 32:359- 372, 1986.
  70. VanBenthuysen KM, McMurtry IF, Horowitz LD. Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylocholine and auguments contractile reactivity in vitro. J Clin Invest 79:265-274, 1987.
  71. O'Brien RF, Robbins RJ, McMurtry IF. Endothelial cells in culture produce a vasoconstrictor substance. J Cellular Physiol 132: 263-270, 1987.
  72. McMurtry IF, Raffestin B. Potential mechanisms of hypoxic pulmonary vasoconstriction. In: The Pulmonary Circulation in Health and Disease, ed. JA Will and EK Weir. Academic Press, 1987, p455-468.
  73. Herget J, McMurtry IF. Dexamethasone potentiates hypoxic vasoconstriction in salt solution-perfused rat lungs. Am J Physiol 253: H574-H581, 1987.
  74. Raffestin B, McMurtry IF. Intracellular alkalosis potentiates hypoxic vasoconstriction in salt solution-perfused rat lungs. J Appl Physiol 63: 2524-2531, 1987.
  75. White CW, Ghezzi P, Dinarello CA, Caldwell SA, McMurtry IF, Repine JE. Recombinant tumor necrosis factor/cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia. J Clin Invest 79:1868-1873, 1987.
  76. Reeves, JT, McMurtry IF, Voelkel NF. Possible role for membrane lipids in the function of the normal and abnormal pulmonary circulation. Am Rev Respir Dis 136:196-199, 1987.
  77. Reeves JT, McMurtry IF. Mediators of hypoxic pulmonary vasoconstriction. In: Hypoxia and Cold, ed., J Sutton, C Houston, and G Coates. New York: Praeger, 1987, p197-206.
  78. Meyrick B, McMurtry IF. Endothelial control of the pulmonary circulation: permeability, tone, and structure-part 1. Am Rev Respir Dis 136:1025-1026, 1987.
  79. Herget J, Frydrychova M, Kawikova I, McMurtry IF. Thyroxine treatment increases the hypoxic pulmonary vasoconstriction in isolated lungs from thyrodectomized rats. Bull Eur Physiopathol Respir 23:217-221, 1987.
  80. McMurtry IF, Rodman DM, Yamaguchi T, O'Brien RF. Pulmonary vascular reactivity. Chest 98:88s-93s, 1988.
  81. Rodman DM, Yamaguchi T, O'Brien RF, McMurtry IF. Methylene blue enhances hypoxic contraction in isolated rat pulmonary arteries. Chest 98:93s-94s, 1988.
  82. White CW, Jackson JH, McMurtry IF, Repine JE. Hypoxia increases glutathione redox cycle and protects rat lungs against oxidants. J Appl Physiol 65:2607-2616, 1988.
  83. Archer SL, McMurtry IF, Weir EK. Mechanisms of acute hypoxic and hyperoxic changes in pulmonary vascular reactivity. In: Pulmonary Vascular Physiology and Pathophysiology, ed. JT Reeves and EK Weir. New York, Marcel Dekker, 1988, 241-290.
  84. Yamaguchi T, Rodman D, O'Brien R, McMurtry I. Modulation of pulmonary artery contraction by endothelium-derived relaxing factor. Eur J Pharmacol 161:259-262, 1989.
  85. Rodman DM, Yamaguchi T, O'Brien RF, McMurtry IF. Hypoxic contraction of isolated rat pulmonary artery. J Pharmacol Exp Ther, 248:952-959, 1989.
  86. Yamaguchi T, O'Brien RF, Hanson W, Wagner WW Jr, McMurtry IF. Prostacyclin contributes to inhibition of hypoxic pulmonary vasoconstriction by alkalosis. Prostaglandins 38:53-63, 1989.
  87. Rodman DM, McMurtry IF, Peach JL, O'Brien RF. Comparative pharmacology of rat and porcine endothelin in isolated rat arteries. Eur J Pharmacol 165:297-300, 1989.
  88. Lesnefsky EJ, Fennessey PM, VanBenthuysen KM, McMurtry IF, Travis VL, Horwitz LD. Superoxide dismutase decreases early reperfusion release of conjugated dienes following regional canine ischemia. Basic Res Cardiol 84:191-196, 1989.
  89. Lesnefsky EJ, VanBenthuysen KM, McMurtry IF, Shikes RH, Johnston RB Jr, Horwitz LD. Lidocaine reduces canine infarct size and decreases release of a lipid peroxidation product. J Cardiovasc Pharmacol 13:895-901, 1989.
  90. Portz SJ, Lesnefsky EJ, VanBenthuysen KM, Repine JE, Parker NB, McMurtry IF, Horwtiz LD. Dimethylthiourea, but not dimethylsulfoxide, reduces canine myocardial infarct size. Free Radical Biol Med 7:53-58, 1989.
  91. Orton EC, Raffestin B, McMurtry IF. Protein Kinase C is a determinant of rat pulmonary vascular reactivity. Am Rev Respir Dis 141:654-658, 1990.
  92. Rodman DM, Yamaguchi T, Haunuma K, O'Brien RF, McMurtry IF. Effects of hypoxia on endothelium-dependent relaxation of rat pulmonary artery. Am J Physiol: Lung Cell Molec Physiol 258:L207-L214, 1990.
  93. Ashmore RC, O'Brien RD, Stelzner TJ, Dauber IM, Horwitz LD, McMurtry IF, VanBenthuysen KM. Aggregating platelets increase intracellular calcium in endothelial cells through release of adenine nucleotides. Biochem Biophys Res Commun 166:909-915, 1990.
  94. Westcott JY, Henson J, McMurtry IF, O'Brien RF. Uptake and metabolism of endothelin in the isolated perfused rat lung. Exp Lung Res 16:521-532, 1990.
  95. Hasunuma K, Rodman DM, O'Brien RF, McMurtry IF. Endothelin-1 causes pulmonary vasodilation in the rat. Am J Physiol: Heart Circ Physiol 259:H48-H54,1990.
  96. Dauber IM, VanBenthuysen KM, McMurtry IF, Wheeler GS, Lesnefsky EJ, Horwitz LD, Weil JV. Functional coronary microvascular injury evident as increased permeability due to brief ischemia and reperfusion. Circ Res 66:986-998, 1990.
  97. Horwitz LD, VanBenthuysen KM, Sheridan FM, Lesnefsky EJ, Dauber IM, McMurtry IF. Coronary endothelial dysfunction from ischemia and reperfusion; effect of reactive oxygen metabolite scavengers. Free Rad Biol Med 8:381-386, 1990.
  98. Dempsey EC, Stenmark KR, McMurtry IF, O'Brien RF, Voelkel NF, Badesch DB. Insulin-like growth factor I and protein kinase C activation stimulate pulmonary artery smooth muscle cell proliferation through separate but synergistic pathways. J Cellular Physiol 144:159-165, 1990.
  99. Abman SH, Chatfield BA, Hall SL, McMurtry IF. Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth. Am J Physiol: Heart Circ Physiol 259:H1921-H1927, 1990.
  100. Rodman DM, Hasunuma K, Peach JL, McMurtry IF. Inhibitor of ATP-sensitive K+ channel alters neither hypoxic contraction nor relaxation of rat aorta. Blood Vessels, 27:365-368, 1990.
  101. Abman SH, Chatfield BA, Hall SL, McMurtry IF. Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth. Am J Physiol: Heart Circ Physiol 259:H1921-1927, 1990.
  102. Lippton HL, Cohen GA, McMurtry IF, Hyman AL. Pulmonary vasodilation to endothelin isopeptides in vivo is mediated by potassium channel activation. J Appl Physiol 70:947-952, 1991.
  103. Hasunuma K, Yamaguchi T, Rodman DM, O'Brien RF, McMurtry IF. Effects of inhibitors of EDRF and EDHF on the vasoreactivity of perfused rat lungs. Am J Physiol: Lung Cellular Molec Physiol. 260:L97-L104, 1991.
  104. Hasunuma K, Rodman DM, McMurtry IF. Effects of K+-channel blockers on vascular tone in the perfused rat lung. Am Rev Respir Dis, 144:884-887, 1991.
  105. Rodman DM, Mallet J, McMurtry IF. Effects of inhibitors of energy metabolism on endothelium-dependent relaxation of rat pulmonary artery and aorta. Am J Resp Cell Molec Biol. 4:237-242, 1991.
  106. Dempsey EC, McMurtry IF, O'Brien RF. Protein kinase C activation allows bovine pulmonary artery smooth muscle cells to proliferate in response to hypoxia. Am J Physiol: Lung Cellular Molec Physiol 260:L136-L145, 1991.
  107. Abman SH, Chatfield BA, Rodman DM, Hall SL, McMurtry IF. Maturational changes in endothelium-derived relaxing factor activity of ovine pulmonary arteries in vitro. Am J Physiol: Lung Cellular Molec Physiol 260:L280-L285, 1991.
  108. Sheridan FM, Horwitz LD, McMurtry IF. Effects of phorbol esters on canine coronary artery constriction and dilation in vitro. Am J Physiol: Heart Circ Physiol 261:H236-H242, 1991.
  109. Ashmore RC, Rodman DM, Sato K, Webb SA, O'Brien RF, McMurtry IF, Stelzner TJ. Paradoxical constriction to platelets by arteries from rats with pulmonary hypertension. Am J Physiol: Heart Circ Physiol 260:H1929-H1934, 1991.
  110. Chatfield BA, McMurtry IF, Hall SL, Abman SH. Hemodynamic effects of endothelin-1 on ovine fetal pulmonary circulation. Am J Physiol: Regulat Integr Comp Physiol 261:R182-R187, 1991.
  111. Lippton HL, Cohen GA, Knight M, McMurtry IF, Gillot D, Arena F, Summer W, Hyman AL. Evidence for distinct endothelin receptors in the pulmonary vascular bed in vivo. J Cardiovasc Pharmacol, 17(Suppl 70:s370-s373, 1991.
  112. Sheridan FM, Dauber IM, McMurtry IF, Lesnefsky EJ, Horwitz LD. Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion. Circ Res 69:1566-1574, 1991.
  113. Sato K, Webb S, Tucker A, Rabinovitch M, O'Brien RF, McMurtry IF, Stelzner TJ. Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat. Am Rev Resp Dis, 145: 793-797, 1992.
  114. Stelzner TJ, O'Brien RF, Yanagisawa M, Sanurai T, Sato K, Webb S, Zamora M, McMurtry IF, Fisher JH. Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension. Am J Physiol: Lung Cellular Molec Physiol 262: L614-L620, 1992.
  115. McMurtry IF, Oka M, Hasunuma K, Yamaguchi T, Morris K, Rodman D. Role of EDRF in control of normoxic and hypoxic pulmonary vascular tone. In: High Altitude Medicine, ed G Ueda, JT Reeves, and M Sekiguchi. Matsumoto, Shinshu University Press, 1992, 131-138.
  116. Rodman DM, Stelzner TJ, Zamora MR, Bonvallet ST, Oka M, Sato K, O'Brien RF, McMurtry IF. Endothelin-1 increases pulmonary microvascular pressure and causes pulmonary edema in salt solution - but not blood-perfused rat lungs. J Cardiovasc Pharmacol 20:658-663, 1992.
  117. Cornfield DN, Chatfield BA, McQueston JA, McMurtry IF , Abman SH. Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus. Am J Physiol: Heart Circ Physiol 262:H1474-H1481, 1992.
  118. Cornfield DN, McQueston JA, McMurtry IF, Rodman DM, Abman SH. Role ATP-sensitive potassium channels in ovine fetal pulmonary vascular tone. Am J Physiol: Heart Circ Physiol 263:H1363-H1368, 1992.
  119. Lanese DM, Yuan BH, McMurtry IF, Conger JD. Comparative sensitivities of isolated rat renal arterioles to endothelin. Am J Physiol: Renal Fluid Electrolyte Physiol 263:F894-F899, 1992.
  120. McQueston JA, Cornfield DN, McMurtry IF, Abman SH. Effects of oxygen and exogenous L-arginine on EDRF activity in fetal pulmonary circulation. Am J Physiol: Heart Circ Physiol 264:H865-H871, 1993.
  121. Oka M, Hasunuma K, Webb SA, Stelzner TJ, Rodman DM, McMurtry IF. Endothelium-derived relaxing factor suppresses an unidentified vasoconstrictor mechanism in hypertensive rat lungs. Am J Physiol: Lung Cellular Molec Physiol 264:L587-L597,1993.
  122. Oka M, Morris KG, McMurtry IF. NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension. J Appl Physiol 75:1075-1080, 1993.
  123. Bonvallet ST, Oka M, Yano M, Zamora MR, McMurtry IF, Stelzner TJ. BQ123, an ETA receptor antagonist, attenuates endothelin-1-induced vasoconstriction in rat pulmonary circulation. J Cardiovasc Pharmacol 22:39-43, 1993.
  124. Stevens T, Morris K, McMurtry IF, Zamora M, Tucker A. Pulmonary and systemic vascular responsiveness to TNF-a in conscious rats. J Appl Physiol 74:1905-1910, 1993.
  125. Cornfield DN, Stevens T, McMurtry IF, Abman SH, Rodman DM. Acute hypoxia increases cytosolic calcium in fetal pulmonary artery smooth muscle cells. Am J Physiol: Lung Cellular Molec Physiol 265:L53-L56, 1993.
  126. Cornfield DN, Stevens T, McMurtry IF, Abman SH, Rodman DM. Acute hypoxia causes membrane depolarization and calcium influx in fetal pulmonary artery smooth muscle cells. Am J Physiol: Lung Cellular Molec Physiol 266:L469-L475, 1994.
  127. Stevens T, Cornfield DN, McMurtry IF, Rodman DM. Acute reductions in PO2 depolarize pulmonary artery endothelial cells and decrease [Ca2+]i. Am J Physiol: Heart Circ Physiol 266:H1416-H1421, 1994.
  128. McQueston JA, Kinsella JP, Ivy DD, McMurtry IF, Abman SH. Chronic pulmonary hypertension in utero impairs endothelium-dependent vasodilation. Am J Physiol: Heart Circ Physiol 268: H288-H294, 1995.
  129. Stevens T, Nakahashi Y, Cornfield D, McMurtry IF, Cooper DMF, Rodman DM. Calcium-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function. Proc Natl Acad Sci 92: 2696-2700, 1995.
  130. Atanasova I, Burke TJ, McMurtry IF, Schrier RW. Nitric oxide synthase inhibition and acute renal ischemia: effect on systemic hemodynamics and mortality. Renal Failure 17: 1-15, 1995.
  131. Niederberger M, Gines P, Tsai P, Martin P-Y, Morris K, Weigert A, McMurtry IF, Schrier RW. Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis. Hepatology 21: 1625-1631, 1995.
  132. Weigert AL, Higa EMS, Niederberger M, McMurtry IF, Raynolds M, Schrier RW. Expression and preferential inhibition of inducible nitric oxide synthase in aortas of endotoxemic rats. J Am Soc Nephrol 5: 2067-2072, 1995.
  133. Gillespie MN, Lipke DW, McMurtry IF. Regulation of pulmonary vasomotor tone in hypertensive pulmonary vascular remodeling. In: Pulmonary Vascular Remodelling, ed., JE Bishop, JT Reeves, and GJ Laurent, London, Portland, 1995, p117-147.
  134. Weigert AL, Martin PY, Niederberger M, Higa EMS, McMurtry IF, Gines P, Schrier RW. Endothelium-dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in aortas of cirrhotic rats. Hepatology 22: 1856-1862, 1995.
  135. Niederberger M, Martin PY, Gines P, Morris K, Tsai P, Xu DL, McMurtry IF, Schrier RW. Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in cirrhotic rats. Gastroenterology 109: 1624-1630, 1995.
  136. Muramatsu M, Tyler RC, Rodman DM, McMurtry IF. Thapsigargin stimulates increased NO activity in hypoxic hypertensive rat lungs and pulmonary arteries. J Appl Physiol 80: 1336-1344, 1996.
  137. Cohen AH, Hanson K, Morris K, Fouty B, McMurtry IF, Clarke W, Rodman DM. Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats. J Clin Invest 97: 172-179, 1996.
  138. Niederberger M, Gines P, Martin PY, Tsai P, Morris K, McMurtry I, Schrier RW. Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus prehepatic portal hypertension in rats. Hepatology 24: 947-951, 1996.
  139. Stevens T, Fouty B, Hepler L, Richardson D, Brough G, McMurtry IF, Rodman DM. Cytosolic Ca++ and adenylyl cyclase responses in phenotypically distinct pulmonary endothelial cells. Am J Physiol: Lung Cellular Molec Physiol 16: L51-L59, 1997. 
  140. Muramatsu M, Oka M, Rodman DM, McMurtry IF. Endothelin-1 mediates nitro-L-arginine vasoconstriction of hypertensive rat lungs. Am J Physiol: Lung Cellular Molec Physiol 16: L807-L812, 1997.
  141. Muramatsu M, Tyler RC, Gutkowska J, Klinger JR, Hill NS, Rodman DM, McMurtry IF. Atrial natriuretic peptide accounts for increased cGMP in hypoxia-induced hypertensive rat lungs. Am J Physiol: Lung Cellular Molec Physiol, 16: L1126-1132, 1997.
  142. Muramatsu M, Tyler RC, Rodman DM, McMurtry IF. Possible role of T-type Ca++ channels in L-NNA vasoconstriction of hypertensive rat lungs. Am J Physiol: Heart Circ Physiol 41: H2616-H2621, 1997.
  143. Chetham PM, Sefton WD, Bridges JP, Stevens T, McMurtry IF. Inhaled nitric oxide pretreatment but not post-treatment attenuates ischemia-reperfusion-induced pulmonary microvascular leak. Anesthesiology 86: 895-902, 1997.
  144. Presson RG, Todoran TM, De Witt BJ, McMurtry IF, Wagner WW. Capillary recruitment and transit time in the rat lung. J Appl Physiol 83: 543-549, 1997.
  145. Tyler RC, Bullock C, Lapuz C, Gorman C, Hepler LK, Tudor RM, McMurtry IF, Rodman DM. Polycationic lipid-mediated gene transfer to the abnormal pulmonary circulation. Chest 111: 122S-123S, 1997.
  146. Fouty B, Muramatsu M, Komalavilas P, Cohen A, McMurtry IF, Lincoln TM, Rodman DM. Protein kinase G is not essential to NO/cGMP modulation of basal tone in the hypertensive pulmonary circulation. Am J Physiol: Heart Circ Physiol 43: H672-H678, 1998.
  147. Le Cras TD, Tyler RC, Horan MP, Morris KG, Tuder RM, McMurtry IF, Johns RA, Abman SH. Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung. J Clin Invest 101: 795-801, 1998.
  148. Fagan K, Hepler LK, McMurtry IF, Rodman DM. Effect of nitric oxide on transgene expression in vascular smooth muscle. Chest 114: 100S-101S, 1998.
  149. Tyler RC, Muramatsu M, Abman SH, Stelzner TJ, Rodman DM, Bloch KD, McMurtry IF. Variable expression of endothelial NOS in three forms of rat pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 20: L297-L303, 1999.
  150. Sato K, Rodman DM, McMurtry IF. Hypoxia inhibits increased ETB receptor-mediated NO synthesis in hypertensive rat lungs. Am J Physiol Lung Cell Mol Physiol 20: L511-L581, 1999.
  151. Fagan KA, Tyler RC, Sato K, Fouty BW, Morris KG, Huang PL, McMurtry IF, Rodman DM. Relative contributions of endothelial, inducible, and neuronal nitric oxide synthase to tone in the murine pulmonary circulation. Am J Physiol Lung Cell Mol Physiol 21: L472-L478, 1999.
  152. Fagan KA, Fouty BW, Tyler RC, Morris KG, Hepler LK, Sato K, Le Cras TD, Abman SH, Weinberger HD, Huang PL, McMurtry IF, Rodman DM. The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Invest 103: 291-299, 1999.
  153. Li KX, Fouty BW, McMurtry IF, Rodman DM. Enhanced ETA-receptor-mediated inhibition of KV channels in hypoxic hypertensive rat pulmonary artery myocytes. Am J Physiol Heart Circ Physiol 46: H363-H370, 1999.
  154. Sato K, Morio Y, Morris KG, Rodman DM, McMurtry IF. Mechanism of hypoxic pulmonary vasoconstriction involves ETA receptor-mediated inhibition of KATP channel. Am J Physiol Lung Cell Mol Physiol, 278: L434-L442, 2000.
  155. Le Cras TD, Markham NE, Morris KG, Ahrens CR, McMurtry IF, Abman SH. Neonatal dexamethasone treatment increases the risk for pulmonary hypertension in adult rats. Am J Physiol Lung Cell Mol Physiol 278: L822-L829, 2000.
  156. Carter E, Sato K, Morio Y, McMurtry IF. Inhibition of KCa channels restores blunted hypoxic pulmonary vasoconstriction in rats with cirrhosis. Am J Physiol Lung Cell Mol Physiol 279: L903-L910, 2000.
  157. McMurtry IF, Rodman DM. Possible reconciliation: a role for endothelin-1 and KATP channels in the mechanism of hypoxic pulmonary vasoconstriction. Cardiopulmonary Crit Care Council Newsletter, 11-14, Fall 2000.
  158. Fagan KA, McMurtry I, Rodman DM. Nitric oxide synthase in pulmonary hypertension: lessons from knockout mice. Physiol Res 49: 539-548, 2000.
  159. Ivy DD, McMurtry IF, Yanagisawa M, Gariepy CE, Le Cras TD, Gebb SA, Morris KG, Abman SH. Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction. Am J Physiol Lung Cell Mol Physiol 280: L1040-L1048, 2001.
  160. Fagan KA, McMurtry IF, Rodman DM. Role of endothelin-1 in lung disease (invited review). Respir Res 2: 90-101, 2001.
  161. Le Cras TD, McMurtry IF. Nitric oxide production in the hypoxic lung (invited review). Am J Physiol Lung Cell Mol Physiol 280: L575-L582, 2001.
  162. Nagaoka T, Muramatsu M, Sato K, McMurtry I, Oka M, Fukuchi Y. Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats. Respir Physiol 127: 53-60, 2001.
  163. Fagan KA, Morrissey B, Fouty BW, Sato K, Harral JW, Morris KG, Hoedt-Miller M, Vidmar S, McMurtry IF, Rodman DM. Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension. Respir Res 2: 306-313, 2001.
  164. Ivy DD, Yanagisawa M, Gariepy CE, Gebb SA, Colvin KL, McMurtry IF. Exaggerated hypoxic pulmonary hypertension in endothelin B receptor deficient rats. Am J Physiol Lung Cell Mol Physiol 282: L703-L712, 2002.
  165. Morio Y, McMurtry IF. Ca2+ release from ryanodine-sensitive store contributes to mechanism of hypoxic vasoconstriction in rat lungs. J Appl Physiol 92: 527-534, 2002.
  166. McMurtry IF. Introduction: pre- and postnatal lung development, maturation, and plasticity (editorial). Am J Physiol Lung Cell Mol Physiol 282: L341-L344, 2002.
  167. Carter EP, Hartsfield CL, Miyazono M, Jakkula M, Morris KG, McMurtry IF. Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome. Am J Physiol Lung Cell Mol Physiol 283: L346-L353, 2002.
  168. Littler CM, Morris KG, Fagan KA, McMurtry IF, Messing RO, Dempsey EC. Protein kinase C epsilon null mice have decreased hypoxic pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol 284: H1321-H1331, 2003.
  169. Morio Y, Cater EP, Oka M, McMurtry IF. EDHF-mediated vasodilation involves different mechanisms in normotensive and hypertensive rat lungs. Am J Physiol Heart Circ Physiol 284: H1762-H1770, 2003.
  170. McMurtry IF, Bauer NR, Fagan KA, Nagaoka T, Gebb SA, Oka M. Hypoxia and Rho/Rho-kinase signaling: lung development versus hypoxic pulmonary hypertension (book chapter). Adv Exper Med Biol 543: 127-137, 2003.
  171. McMurtry IF. Rho family GTPases (editorial). Am J Physiol Lung Cell Mol Physiol 287: L623, 2004.
  172. Fagan KA, Oka M, Bauer NR, Gebb SA, Ivy DD, Morris KG, McMurtry IF. Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol 287: L656-L664, 2004.
  173. Nagaoka T, Morio Y, Casanova N, Bauer N, Gebb S, McMurtry I, Oka M. Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 287: L665-L672, 2004.
  174. Robertson TP, McMurtry IF. Critical role of Ca2+-sensitization in acute hypoxic pulmonary vasoconstriction (chapter 7, p 103). In, Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms, Jason X-J Yuan, Kluwer Academic, 2004.
  175. McMurtry IF, Bauer NR, Gebb SA, Fagan KA, Nagaoka T, Oka M, Robertson TP. Rho/Rho-kinase signaling in hypoxic pulmonary hypertension (chapter 24, p 419). In, Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms, Jason X-J Yuan, Kluwer Academic, 2004.
  176. Tang JR, Markham NE, Lin YJ, McMurtry IF, Maxey A, Kinsella JP, Abman SH. Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor. Am J Physiol Lung Cell Mol Physiol 287: L344-L351, 2004.
  177. Hartsfield CL, McMurtry IF, Ivy DD, Morris KG, Vidmar S, Rodman DM, Fagan KA. Cardio protective and vasomotor effects of HO activity during acute and chronic hypoxia. Am J Physiol Heart Circ Physiol 287: H2009-H2015, 2004.
  178. Imamura M, Luo B, Limbird J, Vitello A, Oka M, Ivy DD, McMurtry IF, Garat CV, Fallon MB, Carter EP. Hypoxic pulmonary hypertension is prevented in rats with common bile duct ligation. J Applied Physiol 98: 739-747, 2005.
  179. Nagaoka T, Fagan KA, Gebb AS, Morris KG, Suzuki T, Shimokawa H, McMurtry IF, Oka M. Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med 171: 494-499, 2005.
  180. Fagan KA, McMurtry IF. Pulmonary vascular pharmacology (chapter 10, p 280). In, Murray and Nadel's Textbook of Respiratory Medicine, fourth edition, RJ Mason, JF Murray, VC Broaddus, JA Nadel, WB Saunders, 2005.
  181. Ivy DD, McMurtry IF, Colvin K, Lee DS, Gebb S, Jones PL. Development of occlusive neointimal lesions in endothelin B receptor-deficient rats: a new model of severe pulmonary arterial hypertension. Circulation 111: 2988-2996, 2005.
  182. Ling X, Cota-Gomez A, Flores NC, Hernandez-Saavedra D, McCord JM, Marecki JC, Haskins K, McDuffie M, Powers K, Kench J, Oka M, McMurtry IF, Flores SC. Alterations in redox homeostasis and prostaglandins impair endothelial-dependent vasodilation in euglycemic autoimmune nonobese diabetic mice. Free Rad Biol Med 39: 1089-1098, 2005.
  183. Stenmark KR, McMurtry IF. Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension; a time for reappraisal? (editorial) Circ Res, 97: 95-98, 2005.
  184. Gupte SA, Okada T, McMurtry IF, Oka M. Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction. Pulm Pharmacol Ther 19: 303-309, 2006.
  185. McMurtry IF, Gebb SA, Jones PL. Pulmonary vascular remodeling (p 591). In, Encyclopedia of Respiratory Medicine, GJ Laurent and SD Shapiro, Elsevier, 2006.
  186. Nagaoka T, Gebb SA, Karoor V, Homma N, Morris KG, McMurtry IF, Oka M. Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. J Appl Physiol 100: 996-1002, 2006.
  187. Garat CV, Fankell D, Erickson PF, Reusch JE-B, Bauer NN, McMurtry IF, Klemm DJ. Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells. Mol Cell Biol 26: 4934-4948, 2006.
  188. Oka M, Karoor V, Homma N, Nagaoka T, Sakao E, Golembeski SM, Limbird J, Imamura M, Gebb SA, Fagan KA, McMurtry IF.  Dehydroepiandrosterone upregulates soluble guanylate cyclase and inhibits hypoxic pulmonary hypertension.  Cardiovasc Res 74:377-387, 2007.
  189. McLoughlin P, McMurtry I.  Counterpoint: Chronic hypoxia-induced pulmonary hypertension does not lead to loss of pulmonary vasculature.  (Invited point/counterpoint)  J Appl Physiol 103: 1451-1454, 2007. 
  190. McLoughlin P, McMurtry I.  Last word on point/counterpoint: Chronic hypoxia does/does not lead to loss of pulmonary vasculature.  J Appl Physiol 103: 1456, 2007.
  191. Oka M, Homma N, Taraseviciene-Stewart L, Morris KG, Kraskauskas D, Voelkel NF, McMurtry IF.  Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.  Circ Res, 100: 923-929, 2007.
  192. Crossno JT, Garat CV, Reusch JEB, Morris KG, Dempsey EC, McMurtry IF, Stenmark KR, Klemm DJ.  Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling.  Am J Physiol Lung Cell Mol Physiol 292: L885-L897, 2007.
  193. Laudi S, Trump S, Schmitz V, West J, McMurtry I, Mutlak H, Christians U, Weimann J, Kaisers U, Steudel W. Serotonin transporter protein in pulmonary hypertensive lungs treated with atorvastatin. Am J Physiol Lung Cell Mol Physiol 293: L630-L638, 2007.
  194. Bauer NR, Moore TM, McMurtry IF.  Rodent models of PAH: Are we there yet?  (editorial) Am J Physiol Lung Cell Mol Physiol 293: L580-L582, 2007.
  195. Homma N, Nagaoka T, Morio Y, Gebb SA, Karoor V, McMurtry IF, Oka M.  Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation.  J Cardiovasc Pharmacol 50: 697-702, 2007.
  196. Oka M, Homma N, McMurtry IF.  Rho kinase-mediated vasoconstriction in rat models of pulmonary hypertension (Invited review).  Methods Enzymol 439: 191-204, 2008.
  197. Homma N, Nagaoka T, Karoor V, Imamura M, Taraseviciene-Stewart L, Walker LA, Fagan KA, McMurtry IF, Oka M.  Involvement of RhoA/Rho kinase signaling in dehydroepiandrosterone's protection against monocrotaline-induced severe pulmonary hypertension in pneumonectomized rats. Am J Physiol Lung Cell Mol Physiol 295: L71-L78, 2008.
  198. Oka M, Fagan KA, Jones PL, McMurtry IF. Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension. Br J Pharmacol 155: 444-454, 2008.
  199. McMurtry IF.  Animal models of human severe PAH.  Adv Pulm Hyper 7:346-349, 2009.
  200. Ward JP, McMurtry IF.  Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem.  Curr Opin Pharmacol 9: 287-296, 2009.
  201. Frye M, McMurtry I, Orton EC, Fagan K.  Use of fat-fed rats to study the metabolic and vascular sequelae of obesity and b-adrenergic antagonism.  Comparative Medicine 59: 1-7, 2009.
  202. Morrell NW, Adnot S, Archer SL, Dupis J, Jones PL, MacLean MR, McMurtry IF, Stenmark KR, Thistlewaite PA, Weissmann N, Yuan JX-J, Weir EK.  Cellular and molecular basis of pulmonary arterial hypertension.  J Am Coll Cardiol 54: S20-S31, 2009.
  203. Stenmark KR, Meyrick B, Galie N, Mooi WJ, McMurtry IF.  Animal models of pulmonary arterial hypertension.  The hope for etiologic discovery and pharmacologic cure?  Am J Physiol Lung Cell Mol Physiol, online September 11, 2009.

Email Newsletters

Connect With Us